儿童噬血细胞综合征早期诊断研究进展  

Research progress on the early diagnosis of pediatric hemophagocytic lymphohistiocytosis

作　　者：卢秀兰 Lu Xiulan(Affiliated Children's Hospital of Xiangya School of Medicine,Central South University(Hunan Children's Hospital),Changsha 410007,China)

机构地区：[1]中南大学湘雅医学院附属儿童医院(湖南省儿童医院),长沙410007

出　　处：《中国小儿急救医学》2024年第11期801-805,共5页Chinese Pediatric Emergency Medicine

基　　金：湖南省自然科学基金面上项目(2023JJ30324);湖南省卫生健康高层次人才重大科研专项(R2023156)。

摘　　要：早期诊断是提高儿童噬血细胞综合征(HLH)预后的关键。然而,HLH的诊断面临诸多挑战,包括缺乏特异性临床表现、早期识别困难、诊断标准复杂,以及部分诊断指标检测周期长等问题。针对这些临床挑战,国内外学者开展了诸多研究,致力于开发新的生物标志物、明确早期识别可疑病例的方法、优化各类型HLH的预测模型和诊断标准、建立清晰的临床诊断路径等。本文总结了儿童HLH早期诊断的国内外研究进展,为推动HLH的早期诊断提供参考。Early diagnosis is crucial for improving the prognosis of hemophagocytic lymphohistiocytosis(HLH).However,diagnosing HLH presents numerous challenges,including lack of specific clinical manifestations,difficulty in early recognition,complex diagnostic criteria,and lengthy testing periods for some diagnostic indicators.To address these clinical challenges,researchers both in China and abroad have conducted various studies aimed at developing new biomarkers,establishing methods for the early identification of suspected cases,optimizing predictive models and diagnostic criteria for different types of HLH,and creating clear clinical diagnostic pathways.This article summarized the research progress on the early diagnosis of pediatric HLH,providing a reference for advancing early diagnosis of the disease.

关 键 词：儿童 噬血细胞综合征 早期诊断 预测模型 生物标志物 诊断路径 

分 类 号：R725.9[医药卫生—儿科]