12周太极心脏康复方案对冠心病患者炎症因子及黏附分子的影响  

Effects of 12 week Tai Chi cardiac rehabilitation programs on inflammatory factors and adhesion molecules in patients with coronary artery disease

作　　者：魏秋阳 彭芳[3] 李亚梦 崔美泽 刘明宇 房辉 张建伟 陈在浩 刘林利 付嘉豪 李浩杰 马雨鑫 张行 吕韶钧 WEI Qiuyang;PENG Fang;LI Yameng(College of Physical Education and Sports,Beijing Normal University,Beijing,100875)

机构地区：[1]北京师范大学体育与运动学院,北京市100875 [2]江苏大学体育部 [3]北京大学体育教研部

出　　处：《中国康复医学杂志》2024年第12期1790-1796,共7页Chinese Journal of Rehabilitation Medicine

基　　金：国家重点研发计划项目(2018YFC2000604)。

摘　　要：目的:观察12周太极心脏康复方案(以下简称心康方案)和常规运动康复方案对冠心病患者炎症因子及黏附分子的影响。方法:于2020年10月至2021年11月,在北京朝阳区安贞社区服务中心、山东淄博万杰康复医院共同招募46例冠心病患者,按1∶1比例随机分为试验组(n=23)和对照组(n=23),最终完成整个试验的患者为34例,试验组14例,对照组20例。采用太极心康方案干预试验组,采用常规运动康复方案干预对照组,每周干预3次,每次60min,共计干预12周,其中包括4周医院院内康复和8周远程线上的居家康复。在干预前后检测炎症因子和黏附分子。结果:12周干预后,两组C-反应蛋白(CRP)、白介素-6(IL-6)、血管细胞黏附分子(VCAM-1)、细胞间黏附分子(ICAM-1)较干预前均显著下降(P<0.01);太极心康方案组抗炎因子白介素-10(IL-10)较干预前显著上升(P<0.01)。干预前两组组间比较各指标均无显著性差异(P>0.05),干预后太极心康方案组VCAM-1显著低于常规运动康复方案组(P<0.05)。结论:12周太极心康方案和常规运动康复方案干预,均能有效降低冠心病患者促炎因子CRP、IL-6水平和黏附分子ICAM-1、VCAM-1水平。与常规运动康复方案相比,太极心康方案可有效提高抗炎因子IL-10水平,显著减少黏附分子VCAM-1的表达,对调控冠心病患者机体促炎与抗炎平衡,改善机体抗黏附能力具有更积极的作用。Objective:To observe The effects of 12-week Tai Chi Cardiac Rehabilitation Programme(TCCRP)and conventional exercise rehabilitation program(CERP)on inflammatory factors and adhesion molecules in patients with coronary heart disease(CHD).Method:Forty-six patients with CHD were jointly recruited from Anzhen Community Service Center at Beijing Chaoyang District and Wanjie Rehabilitation Hospital at Shandong Zibo from Oct.2020 to Nov.2021,and were randomly divided into the TCCRP group(n=23)and the CERP group as the control group(n=23)according to a 1∶1 ratio.Thirty-four patients completed the whole program,14 patients in the TCCRP group and 20 patients in the CERP group.All program were 60 min per time,3 times a week for a total of 12 weeks,including 4 weeks of in-hospital rehabilitation and 8 weeks of remote on-line home-based rehabilitation.Inflammatory factors and adhesion molecules were detected before and after the intervention.Result:After 12 weeks of intervention,C-reactive protein(CRP),interleukin 6(IL-6),vascular cell adhesion molecule(VCAM-1),and intercell adhesion molecule(ICAM-1)all decreased significantly(P<0.01).The anti-inflammatory factor interleukin 10(IL-10)increased significantly in the TCCRP group(P<0.01).There was no significant difference between the two groups before the intervention(P>0.05),and the VCAM-1 in the TCCRP group was significantly lower than the CERP group after the intervention(P<0.05).Conclusion:In patients with coronary heart disease,the 12-week TCCRP and CERP intervention can effectively reduce the levels of pro-inflammatory factors CRP,IL-6 and adhesion molecules ICAM-1 and VCAM-1.The TCCRP can effectively improve the level of anti-inflammatory factor IL-10 and reduce the expression of adhesion molecule VCAM-1 compared with CERP,which indicate a more positive effect on regulating the balance between pro-inflammatory and anti-inflammatory factors and improving the anti-inflammatory and anti-adhesion ability.

关 键 词：太极心脏康复方案 常规运动康复方案 冠心病 促炎因子 抗炎因子 黏附分子 

分 类 号：R541.4[医药卫生—心血管疾病] R493[医药卫生—内科学]