基于放射生物学模型的放疗中断补量计算及其临床应用  

Compensatory calculation of radiotherapy interruption based on radiobiological modeling and its clinical application

作　　者：苏欢繁 马莉 权恩卓 代智涛 SU Huanfan;MA Li;QUAN Enzhuo;DAI Zhitao(Department of Medical Imaging,Jiangxi Medical College,Shangrao 334000,China;National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen 518100,China)

机构地区：[1]江西医学高等专科学校医学影像学院,江西上饶334000 [2]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院深圳医院,广东深圳518100

出　　处：《中国医学物理学杂志》2024年第12期1473-1480,共8页Chinese Journal of Medical Physics

基　　金：江西省级引导市县科技发展专项资金项目(2023AB013);深圳市“医疗卫生三名工程”项目(SZSM202211030);深圳市医学重点学科建设经费资助(SZXK013);中国医学科学院肿瘤医院深圳医院临床重点专科肿瘤科项目(SZXK013);江西省教育厅科学技术研究项目(GJJ213410);江西医学高等专科学校自然科学项目(JYKJ-2022-16)。

摘　　要：放疗中断导致的总治疗时间延长对肿瘤局部控制有害。肿瘤患者放疗疗程中出现中断事件有多种因素,包括公共假期、机器故障与维护、放疗并发症等。若放疗过程中不可避免地出现中断治疗事件,应该采取补偿措施以尽量减少放疗中断对肿瘤控制的影响。因此,本文从放射治疗中断的原因与影响、中断补偿的思路进行概括讨论;并且对于放疗中断补量的生物学模型进行归纳总结,如名义标称剂量模型、累积放射效应模型、时间-剂量分次因子模型、生物效应剂量模型等;同时以鼻咽癌为例来对临床肿瘤放疗的中断补量计算等进行系统阐述,以期为临床肿瘤放疗中断补量的定量计算提供参考。Prolonged total treatment time due to radiotherapy interruptions is detrimental to local tumor control.There are multiple causes that contribute to the occurrence of interruption events during radiotherapy,including public holidays,machine breakdown and maintenance,and radiotherapy complications.If treatment interruption events are unavoidable during radiotherapy,compensatory approaches should be taken to minimize the effects of radiotherapy interruptions on tumor control.Herein the study provides a summary on the causes and influence of radiotherapy interruptions,the ideas of interruption compensation,and the biological models of radiotherapy interruption compensation,such as nominal standard dose,cumulative radiation effect,time-dose fractionation factors,biologically effective dose models,etc.Additionally,the compensatory calculation for radiotherapy interruption in nasopharyngeal carcinoma is taken as an example to provide a reference for the quantitative compensation calculation for radiotherapy interruption in clinic.

关 键 词：放射生物学 放疗中断 补量计算 生物效应剂量模型 

分 类 号：R318[医药卫生—生物医学工程] R811.1[医药卫生—基础医学]