pH-controlled reversible sol-gel inversion by cerous phosphate nanofibers for hemostasis  

作　　者：Tuo Su Jun-Chen Xu Wei Yu Dan Su Di-Er Shi Yi-Chao Pang Yao Ying Wang-Chang Li Juan Li Jing-Wu Zheng Liang Qiao Sheng-Lei Che Jing Yu 

机构地区：[1]Research Center of Magnetic and Electronic Materials,College of Materials Science and Engineering,Zhejiang University of Technology,Hangzhou 310014,China [2]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310000,China [3]Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province,Department of Clinical Medicine,Hangzhou Medical College,Hangzhou 310053,China [4]Department of Chemistry,Zhejiang University,Hangzhou 310027,China [5]Clinical Medical College,Yangzhou University,Yangzhou 225001,China

出　　处：《Rare Metals》2024年第10期5141-5151,共11页稀有金属（英文版）

基　　金：financially supported in part by the Natural Science Foundation of Zhejiang Province(No.LR22E010001);the National Natural Science Foundation of China(No.52073258);the Fundamental Research Funds for the Provincial Universities of Zhejiang(No.RF-B2022006);the R&D Program of Zhejiang University of Technology(No.KYY-HX-20190730)。

摘　　要：Developing biomimetic soft materials that display stimuli responsiveness using solely inorganic materials has been regarded as a challenge owing to that such materials?properties typically vary from those of living organisms.Traditionally,biomimetic soft materials have been developed using organic materials or inorganic materials modified with organic small molecules.In this study,we prepared cerium phosphate nanofibers(CePO_(4)NFs)by using inorganic agents only without further modification.The CePO_(4)NFs demonstrate sol-ge switching properties in response to pH value,allowing them to form a gel under high hydroxide ion(OH^(-))concentrations and turn back into sol under low OH^(-)concentrations.The formation of gel could be ascribed to the physical cross-linking of the nanofibers induced by the attractive electrostatic force of OH^(-)and surface Ce^(3+).As a result,CePO_(4)NFs are able to form a gel when in contac with blood of high pH value for hemostasis.This specific clotting mechanism makes them better candidates for hemostasis of heavy bleeding.

关 键 词：Cerium phosphate nanofibers PH-RESPONSIVE REVERSIBLE Sol-gel switching HEMOSTASIS 

分 类 号：TB383.1[一般工业技术—材料科学与工程] TQ343[化学工程—化纤工业] R318.08[医药卫生—生物医学工程]