Bio-inspired barnacle cement coating of biodegradable magnesium alloy for cerebrovascular application  

作　　者：Hang Li Fei Wang Xiao-Jing Sun Liu-Jie Qi Jing-An Li Mujahid Iqbal Shao-Kang Guan 

机构地区：[1]School of Material Science and Engineering,Zhengzhou University,Zhengzhou 450000,China [2]Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold(Ministry of Education),Zhengzhou University,Zhengzhou 450000,China [3]Department of Physics,University of Agriculture Faisalabad,Faisalabad 38000,Pakistan

出　　处：《Rare Metals》2024年第10期5164-5185,共22页稀有金属（英文版）

基　　金：financially supported by the National Key Research and Development Program of China(No.2021YFC2400703);the Joint Fund of the National Natural Science Foundation of China(No.U2004164);Key Scientific and Technological Research Projects in Henan Province(Nos.232102311155 and 232102230106);Zhengzhou University Major Project Cultivation Special Project(No.125-32214076)。

摘　　要：Ischemic stroke is increasing worldwide,and stent intervention has gradually become one of the effective treatments.Owing to its good mechanical properties and biocompatibility,biodegradable Mg-Zn-Y-Nd alloy(ZE21B)has good application prospects in vascular stents.However,too fast degradation and delayed endothelialization are the bottleneck problem to limit its further application.In this study,the bio-inspired coating barnacle cement cp19k is constructed on ZE21B surface through electrostatic spraying to improve the corrosion resistance and pro-endothelialization ability.The coating was evaluated through electrochemistry,static immersion corrosion,in vitro blood experiments and cell experiments.Cp19k effectively improved the corrosion resistance of the substrate ZE21B,reduced the degradation rate,improved endothelial cell proliferation and migration capabilities,inhibited smooth muscle cells proliferation and regulated contractile phenotype,inhibited macrophage adhesion,regulated macrophage M2 phenotype,and reduced the expression of inflammatory factor of TNF-a and inhibited fibroplasia in vivo.Our data indicated that the barnacle cement cp19k coating had potential application on the surface modification of Mg alloy cerebrovascular stent.

关 键 词：Cerebrovascular stent Biodegradable magnesium alloy Barnacle cement cp19k Proendothelialization M2 phenotype 

分 类 号：TG174.4[金属学及工艺—金属表面处理] R318.08[金属学及工艺—金属学]