Microwave excited hyperthermy and catalysis of heterostructured Au/Cu–BTA for effective bacteria killing by accelerating charge separation  

作　　者：Wen-Jing Zhang Li-Guo Jin Shui-Lin Wu Chao-Feng Wang Yu-Feng Zheng Zhao-Yang Li Zhen-Duo Cui Hui Jiang Sheng-Li Zhu Xiang-Mei Liu 

机构地区：[1]School of Materials Science and Engineering,the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China,Tianjin University,Tianjin 300072,China [2]Biomedical Materials Engineering Research Center,Hubei Key Laboratory of Polymer Materials,Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials,School of Materials Science&Engineering,Hubei University,Wuhan 430062,China [3]School of Materials Science and Engineering,Peking University,Beijing 100871,China [4]School of Health Science and Biomedical Engineering,Hebei University of Technology,Tianjin 300401,China

出　　处：《Rare Metals》2024年第10期5186-5201,共16页稀有金属（英文版）

基　　金：financially supported by the China National Funds for Distinguished Young Scientists(No.51925104);the National Natural Science Foundation of China(No.52173251);NSFC-Guangdong Province Joint Program(Key program No.U21A2084);the Central Guidance on Local Science and Technology Development Fund of Hebei Province(No.226Z1303G);Yanzhao Young Scientist Project(No.C2023202018)and Beijing Natural Science Foundation(No.7232338)。

摘　　要：Deep tissue infections caused by pathogenic bacteria seriously threat the lives of patients.In this study a smart heterostructured Au/Cu-BTA(BTA=1,2,4,5-benzenetetramine)with microwave(MW)response is synthesized via NaBH_(4)reduction of HAuCl_(4)on the Cu-BTA.Au/Cu-BTA exhibits excellent hyperthermy and dynamics under MW irradiation.The MW thermal mechanism of Au/Cu-BTA is attributed to the excellen dielectric loss and polarization of the heterogeneous interface.Meanwhile,the surface energy levels of the Cu-BTA interface alleviate the difficulty of electron hopping through multistage transition.Therefore,MW can excite Cu-BTA to produce free electrons.Subsequently,Au nanoparticles rapidly increase electron transfer and inhibit electron-hole recombination.Hence,the yields of reactive oxygen species can be enhanced for MW dynamic therapy Consequently,under 10 min of MW irradiation,Au/Cu-BTA killed 99.998%±0.001% of Gram-positive Staphylococcus aureus,99.966%±0.014% of methicillin-resistant Staphylococcus aureus,and 96.871%±0.831% of Gram-negative Pseudomonas aeruginosa.The effective MW bacteria-killing strategy designed in this study shows significant potential for application in the MW-responsive treatment of deep tissue infections without antibiotics.

关 键 词：Microwave therapy ANTIBACTERIAL Antiinfection 

分 类 号：R318.08[医药卫生—生物医学工程]