消胀通便膏在晚期肝癌患者阿片类药物相关性便秘中的应用研究  

Application of eliminating flatulence and laxative cream in advanced hepatocellular carcinoma patients with opioid-associated constipation

作　　者：何亚伦 祁智 常杰 HE Yalun;QI Zhi;CHANG Jie(Department of Integrated Chinese and Western Medicine,the Third Affiliated Hospital of Naval Medical University,Shanghai 201805,China;Department of Nephrology and Neurology,the Third Affiliated Hospital of Naval Medical University,Shanghai 201805,China;Emergency Department,the Third Affiliated Hospital of Naval Medical University,Shanghai 201805,China)

机构地区：[1]海军军医大学第三附属医院中西医结合科,上海201805 [2]海军军医大学第三附属医院肾内/神经内科,上海201805 [3]海军军医大学第三附属医院急诊科,上海201805

出　　处：《药学实践与服务》2024年第12期520-523,共4页Journal of Pharmaceutical Practice and Service

基　　金：海军军医大学第三附属医院护理科研基金(2020HL002)。

摘　　要：目的探讨消胀通便膏在晚期肝癌阿片类药物相关性便秘(OIC)中的应用情况。方法选取2021年6月至2022年12月在海军军医大学第三附属医院诊治的120名晚期肝癌合并OIC患者作为研究对象。采用随机数字表法将患者分为对照组(乳果糖+常规治疗)与试验组(消胀通便膏+常规治疗),比较两组排便情况、生活质量以及治疗后的综合评价(包括经济成本、腹泻发生次数以及阿片类药物使用剂量是否有变化)。结果干预28 d后,两组患者在缓解OIC方面均有较好的效果(P<0.05),对于晚期肝癌患者生活质量、经济成本及腹泻次数方面,试验组均显著优于对照组(P<0.05)。结论在治疗晚期肝癌患者OIC中,使用外敷消胀通便膏和口服乳果糖液均可缓解便秘症状。其中,消胀通便膏更易被患者接受,且在生活质量和经济成本方面更优,对提高患者满意度和安全性是一个更佳的选择。Objective To evaluate the curative effect ofeliminating flatulence and laxative cream on patients with advanced hepatocellular carcinoma and opioid-associated constipation(OIC).Methods 120 patients with advanced liver cancer complicated with OIC who were treated at the Third Affiliated Hospital of Naval Medical University from June 2021 to December 2022 were selected as the study subjects.The patients were divided into a control group(lactulose+conventional treatment)and an experimental group(eliminating flatulence and laxative cream+conventional treatment)using a randomized numerical table method.Two groups were compared in terms of defecation,quality of life,and comprehensive post-treatment evaluation(economic cost,number of occurrences of diarrhea,and whether or not there was a change in the dosage of opioids used).Results After 28 d of intervention,both groups showed better results in relieving OIC(P<0.05),and the experimental group was significantly better than the control group in terms of the quality of life of patients with advanced hepatocellular carcinoma,the economic cost and the number of diarrhea(P<0.05).Conclusion In the treatment of OIC in patients with advanced hepatocellular carcinoma,constipation could be relieved by using both topicaleliminating flatulence and laxative cream and oral lactulose solution.Among them,antieliminating flatulence and laxative cream was more acceptable to patients and superior in terms of quality of life and economic cost,which could be a better choice for improving patient satisfaction and safety.

关 键 词：阿片类药物相关性便秘 晚期肝癌 穴位贴敷 中药膏剂 

分 类 号：R285.6[医药卫生—中药学]