比索洛尔对冠心病介入术后心脏舒张功能及预后的影响观察  

Effect of Bisoprolol on Cardiac Diastolic Function and Prognosis in Patients after Coronary Heart Disease Interventional Surgery

作　　者：王真真 张海波 李运丽 WANG Zhen-zhen;ZHANG Hai-bo;LI Yun-li(Cardiovascular Medicine,The First Affiliated Hospital of Henan University,Kaifeng 475000,Henan Province,China)

机构地区：[1]河南大学第一附属医院心血管内科,河南开封475000

出　　处：《罕少疾病杂志》2024年第12期57-58,共2页Journal of Rare and Uncommon Diseases

基　　金：河南省开封市科技发展计划项目(1903048)。

摘　　要：目的观察比索洛尔对冠心病介入术后患者心脏舒张功能及预后的影响。方法选取2021年12月至2023年4月于本院行冠心病介入术的患者92例,采用随机数字表法将其分为干预组(n=46)和对照组(n=46),其中对照组采用阿司匹林进行治疗,观察组在对照组的基础上联合比索洛尔进行治疗,比较两组患者治疗前及治疗后的心脏功能(心排出量、心脏指数、射血分数),比较两组患者治疗前及治疗后的NYHA心功能分级,比较两组患者的不良反应(低血压、头晕目眩、四肢发冷)发生率。结果治疗后,两组患者的心脏功能以及NYHA心功能分级均较治疗前显著改善(P<0.05),且观察组显著优于对照组(P<0.05),观察组低血压、头晕目眩、四肢发冷以及不良反应的总发生率均无显著统计学差异(P>0.05)。结论冠心病介入术患者在使用阿司匹林的基础上采用比索洛尔治疗能更有效的改善患者的心脏舒张功能,且其具有一定的安全性,可在临床上推广使用。Objective To observe the effect of bisoprolol on cardiac diastolic function and prognosis in patients after coronary heart disease interventional surgery.Methods 92 patients who underwent coronary heart disease interventional surgery in our hospital from December 2021 to April 2023 were selected and divided into intervention group(n=46)and control group(n=46)by the random number table method.The control group was treated with aspirin,and the observation group was given bisoprolol on the basis of the control group.The cardiac function(cardiac output,cardiac index and ejection fraction)before and after treatment,NYHA cardiac function grading before and after treatment and incidence rates of adverse reactions(hypotension,light-headedness,cold limbs)were compared between the two groups.Results After treatment,the cardiac function and NYHA cardiac function grading in the two groups were significantly improved compared with those before treatment(P<0.05),and the above indicators in observation group were significantly better than those in control group(P<0.05).There were no statistically significant differences in the incidence rates of hypotension,light-headedness and cold limbs and total incidence rate of adverse reactions between both groups(P>0.05).Conclusion Bisoprolol therapy on the basis of aspirin can effectively improve the cardiac diastolic function in patients after interventional surgery for coronary heart disease,and it has certain safety,and can be widely used in clinical practice.

关 键 词：比索洛尔 冠心病介入术 心脏舒张功能 

分 类 号：R541.4[医药卫生—心血管疾病]