血清Hcy、hs-CRP水平变化评估冠心病颈动脉内中膜厚度临床意义  

Clinical Significance of Changes in Serum Hcy and Hs-CRP Levels in Evaluating Carotid Intima-media Thickness in Patients with Coronary Heart Disease

作　　者：朱俊 王静 任红玲 李磊 ZHU Jun;WANG Jing;REN Hong-ling;LI Lei(Laboratory Department,Zhumadian Traditional Chinese Medicine Hospital,Zhumadian 463000,Henan Province,China;Ultrasonic Department,Zhumadian Traditional Chinese Medicine Hospital,Zhumadian 463000,Henan Province,China)

机构地区：[1]驻马店市中医院检验科,河南驻马店463000 [2]驻马店市中医院超声科,河南驻马店463000

出　　处：《罕少疾病杂志》2024年第12期59-61,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)水平与冠心病患者颈动脉内中膜厚度(IMT)的相关性。方法选取2020年8月至2022年8月我院收治的冠心病患者65例作为观察组,另选同期健康体检者65例作为对照组。所有研究对象均采血检测Hcy、hs-CRP水平,并使用超声检查颈动脉IMT水平,比较两组血清Hcy、hs-CRP水平、颈动脉IMT差异;并依据冠心病类型分为急性心肌梗死、不稳定型心绞痛及稳定型心绞痛三组,比较三组间血清Hcy、hs-CRP水平、颈动脉IMT差异;采用Pearson相关性分析冠心病患者血清指标水平与颈动脉IMT的相关性;绘制ROC曲线分析血清指标诊断冠心病的临床价值。结果观察组血清Hcy、hs-CRP水平、颈动脉IMT高于对照组,有统计学差异(P<0.05);急性心肌梗死患者血清Hcy、hs-CRP水平、颈动脉IMT高于不稳定型冠心病、稳定型冠心病,有统计学差异(P<0.05);经Pearson相关性分析显示,血清Hcy、hs-CRP水平与动脉IMT呈正相关(r值=0.396、0.372,P值=0.000、0.000);绘制ROC曲线分析显示,血清Hcy、CRP及联合检测诊断冠心病的曲线下面积分别为0.841、0.818、0.973,联合检测曲线下面积更高。结论血清Hcy、hs-CRP水平诊断冠心病的价值高,且Hcy、hs-CRP水平与颈动脉IMT存在正相关性,能够评估患者病情严重程度,推荐作为早期重要检测指标。Objective To investigate the correlation between serum homocysteine(Hcy)and hypersensitive C-reactive protein(hs-CRP)levels and carotid intima-media thickness(IMT)in patients with coronary heart disease.Methods Sixty-five patients with coronary heart disease admitted to our hospital from August 2020 to August 2022 were selected as the observation group,and 65 healthy subjects were selected as the control group during the same period.Blood samples of all subjects were collected to detect the levels of Hcy and hc-CRP,and ultrasound was used to detect the levels of carotid IMT.The serum levels of Hcy,hs-CRP and carotid IMT were compared between the two groups.According to the type of coronary heart disease,they were divided into three groups:acute myocardial infarction,unstable angina pectoris and stable angina pectoris.The differences of serum Hcy,hs-CRP and carotid IMT among the three groups were compared.Pearson correlation was used to analyze the correlation between serum index level and carotid IMT in patients with coronary heart disease.ROC curve was drawn to analyze the clinical value of serum indexes in diagnosing coronary heart disease.Results The levels of serum Hcy,hs-CRP and carotid IMT in observation group were higher than those in control group,with statistical difference(P<0.05).The levels of serum Hcy,hs-CRP and carotid IMT in patients with acute myocardial infarction were higher than those of unstable coronary heart disease and stable coronary heart disease,with statistical differences(P<0.05).Pearson correlation analysis showed that serum Hcy and hs-CRP levels were positively correlated with arterial IMT(r=0.396,0.372,P=0.000,0.000).ROC curve analysis showed that the areas under the curve of serum Hcy,CRP and combined detection in diagnosing CHD were 0.841,0.818 and 0.973,respectively,and the areas under the combined detection curve were higher.Conclusion Serum Hcy and hs-CRP levels have high value in the diagnosis of coronary heart disease,and there is a positive correlation between Hcy and hs-CRP

关 键 词：冠心病 颈动脉内中膜厚度 同型半胱氨酸 诊断价值 

分 类 号：R541.4[医药卫生—心血管疾病]