口服vitD对绝经后乳腺癌内分泌治疗骨密度及相关事件的影响  

Effect of Oral vitD on Endocrine Therapy BMD and Related Events in Postmenopausal Breast Cancer Patients

作　　者：邱炜 王雨辰 QIU Wei;WANG Yu-chen(Thyroid and Breast Surgery Department,Fujian Provincial Hospital North Branch,Fujian Provincial Geriatric Hospital,Fuzhou 350000,Fujian Province,China;Basic Surgery,Fujian Provincial Hospital North Branch,Fujian Provincial Geriatric Hospital,Fuzhou 350000,Fujian Province,China)

机构地区：[1]福建省立医院北院福建省老年医院甲状腺乳腺外科,福建福州350000 [2]福建省立医院北院福建省老年医院基本外科,福建福州350000

出　　处：《罕少疾病杂志》2024年第12期116-118,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨口服维生素D联合内分泌治疗对绝经后乳腺癌患者骨相关事件(SREs)及疼痛数字评分(NRS)、骨密度的影响。方法选取我院外科2021年1月至2022年8月期间随访的110例绝经后乳腺癌患者,通过便利抽样法将患者分为对照组(n=50)和研究组(n=60)。对照组给予单纯内分泌治疗,研究组在单纯内分泌治疗基础上联合给予维生素D治疗。比较两组NRS评分、骨密度(BMD)、血脂水平以及SREs发生率。结果治疗后研究组NRS评分显著优于对照组(P<0.05);治疗后研究组TG、LDL-C升高水平显著低于对照组(P<0.05);治疗后研究组BMD降低水平均显著低于对照组(P<0.05);研究组SREs发生率明显低于对照组(P<0.05)。结论维生素D联合内分泌治疗绝经后乳腺癌可有效减轻患者痛苦以及SREs发生率,改善血脂水平,值得临床推广和应用。Objective To explore the effect of vitamin D combined with endocrine therapy on bone-related events(SREs),pain digital score(NRS),and bone mineral density in postmenopausal breast cancer patients.Methods 110 postmenopausal breast cancer patients who were followed up in our hospital from January 2021 to August 2022 were selected and divided into control group(n=50)and research group(n=60)by convenient sampling.The control group received simple endocrine therapy,while the research group received a combination of vitamin D therapy on the basis of simple endocrine therapy.Compare the NRS score,bone mineral density(BMD),blood lipid levels,and incidence of SREs between the two groups.Results The NRS score in the study group was significantly better than control(P<0.05);the TG,LDL-C was significantly lower after treatment than control(P<0.05);the BMD was significantly lower after treatment(P<0.05);and the SREs was significantly lower than the control group(P<0.05).Conclusion Vitamin D combined with endocrine treatment for postmenopausal breast cancer can effectively reduce the pain and incidence of SREs in patients,and improve the blood lipid level,which deserves clinical promotion and application.

关 键 词：维生素 内分泌治疗 绝经后乳腺癌 骨相关事件 疼痛数字评分 骨密度 血脂 

分 类 号：R977.24[医药卫生—药品]