消渴丸与盐酸二甲双胍联合治疗2型糖尿病的临床疗效及对糖代谢的影响  

Clinical Efficacy of Thirst Pill and Metformin Hydrochloride in Type 2 Diabetes and Effect on Glucose Metabolism in Patients

作　　者：吴敏 林宏忠 WU Min;LIN Hong-zhong(Technical Equipment Department,Yichun Emergency Rescue Center Yichun 336000,Jiangxi Province,China)

机构地区：[1]宜春市紧急救援中心技术装备科,江西宜春336000

出　　处：《罕少疾病杂志》2024年第12期143-145,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探究消渴丸与盐酸二甲双胍联合治疗2型糖尿病的临床疗效及对患者糖代谢的影响。方法纳入我院2020年6月至2023年2月收治的62例2型糖尿病患者,按随机数字表法分2组,各31例。对照组口服盐酸二甲双胍,观察组联合消渴丸治疗,均持续治疗3个月。比较两组中医证候积分、临床疗效、糖代谢、不良反应。结果观察组治疗总有效率(93.55%)高于对照组(74.19%),差异有统计学意义(P<0.05);治疗前,两组中医证候积分、糖代谢比较,无统计学差异(P>0.05);观察组治疗后咽干口燥评分(1.06±0.13)分、倦怠乏力评分(0.98±0.11)分、多食易饥评分(0.89±0.07)分、口渴喜饮评分(0.96±0.14)分、气短懒言评分(0.89±0.11)分、五心烦热评分(0.88±0.09)分、心悸失眠评分(0.85±0.08)分、溲赤便秘评分(0.86±0.07)分均低于对照组,空腹血糖(FPG)(5.96±0.87)mmol/L、餐后2h血糖(2hPG)(8.96±1.07)mmol/L、糖化血红蛋白(HbA1c)(6.11±0.59)%均低于对照组,有统计学差异(P<0.05);对比两组不良反应,无统计学差异(P>0.05)。结论消渴丸与盐酸二甲双胍联合治疗2型糖尿病能够有效调节糖代谢,减轻临床症状,且安全性高。Objective To explore the clinical efficacy of thirst pill and metformin hydrochloride in type 2 diabetes mellitus and its effect on glucose metabolism.Methods 62 patients with type 2 diabetes admitted to our hospital from June 2020 to February 2023 were divided into 2 groups with 31 cases each.The control group received oral metformin hydrochloride,and the observation group was combined with thirst pills,all continuing treatment for 3 months.The two groups compared the TCM syndrome score,clinical efficacy,glucose metabolism and adverse effects.Results The overall response rate in the observation group(93.55%)was higher than that of the control group(74.19%),The difference was statistically significant(P<0.05);pretherapy,Comparison of TCM syndrome integration and glucose metabolism between the two groups,No statistical difference(P>0.05);In the observation group,dry throat score(1.06±0.13),burnout score(0.98±0.11),multiple food hunger score(0.89±0.07),thirst score(0.96±0.14),shortness of breath(0.89±0.11),five upset fever score(0.88±0.09),palpitations and insomnia score(0.85±0.08),and constipation score(0.86±0.07)were all lower than the control group,Fasting blood glucose(FPG)(5.96±0.87)mmol/L,2h postprandial blood glucose(2hPG)(8.96±1.07)mmol/L,glycosylated hemoglobin(HbA1c)(6.11±0.59)% were lower than the control group,Statistical difference(P<0.05).Comparing the two groups of adverse effects,There was no statistical difference(P>0.05).Conclusion The combined treatment of metformin hydrochloride in type 2 diabetes can effectively regulate glucose metabolism,reduce clinical symptoms and have high safety.

关 键 词：2型糖尿病 消渴丸 盐酸二甲双胍 中医证候 糖代谢 

分 类 号：R587.1[医药卫生—内分泌]