中药汤剂中相态的形成表征及其药效作用研究进展  

Research Progress on Phase State and Clinical Application of Traditional Chinese Medicine Decoction

作　　者：杨勋玥 简龄龙 杨梅[1] 董欢欢 陈丽华[1] 管咏梅 朱卫丰[1] YANG Xunyue;JIAN Linglong;YANG Mei;DONG Huanhuan;CHEN Lihua;GUAN Yongmei;ZHU Weifeng(College of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学药学院,南昌330004

出　　处：《中国药学杂志》2024年第20期1917-1924,共8页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(82260765);江西中医药大学科技创新团队发展计划资助(CXTD-22004)。

摘　　要：中药汤剂为复杂的分散体系,其有效成分多以溶质或分散相在分散介质中形成不同相态,如真溶液、胶体相、混悬相等。汤剂中各相态的形成、转化、传递等过程可能影响药效成分在生物体内的代谢及作用过程。近年来,对中药汤剂中相态差异及有效相态的研究尚在起步阶段。笔者拟从中药汤剂中有序相态的形成、表征、转化、传递及效应机制等多角度探究中药汤剂的质量基础及作用机制,展望基于物相结构的中药质量研究模式,为从结构中药学的角度解释中药汤剂的效应机制研究提供参考依据。Traditional Chinese medicine(TCM)decoction is a complex dispersion system,and its active components are mostly to form different phases in the form of solutes or dispersed substances,such as true solution,colloidal phase,suspension phase,etc.The active components are complex and diverse,and the formation,transformation,and transmission of each phase may affect the metabolism and action process of the pharmacodynamic components in biological bodies.However,the study on the phase differences and effective phases in TCM decoction is still in the initial stage.In this paper,we will be explored the quality basis and mechanism of TCM decoction from the perspectives of the formation,characterization,transformation,transmission and mechanism of the ordered phase in TCM decoction,and look forward to the quality research mode of TCM based on phase structure,so as to provide a reference for explaining the effect mechanism of TCM decoction from the perspective of structural TCM decoction.

关 键 词：中药汤剂 相态 相态差异 药效 生物转运 相态拆分 相态表征 

分 类 号：R282[医药卫生—中药学]