Sympathetic nerve signals: orchestrators of mammary development and stem cell vitality  

作　　者：Zi Ye Yu Xu Mengna Zhang Cheguo Cai 

机构地区：[1]Department of Pulmonary Oncology,Hubei Province Cancer Clinical Study Center,Hubei Key Laboratory of Tumor Biological Behaviors,Zhongnan Hospital of Wuhan University,Frontier Science Center for Immunology and Metabolism,Medical Research Institute,Wuhan University,Wuhan 430071,China [2]Key Laboratory of Systems Health Science of Zhejiang Province,School of Life Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024,China

出　　处：《Journal of Molecular Cell Biology》2024年第5期29-45,共17页分子细胞生物学报（英文版）

基　　金：This work was supported by grants from the Ministry of Science and Technology of China(National Program on Key Basic Research Project:2019YFA0802804 to L.Y.);the National Natural Science Foundation of China(31871492 and 32270837 to C.C.);Hubei Provincial Natural Science Foundation(2023AFB784 to Y.X.);the Fundamental Research Funds for the Central Universities(2042022kf1146 to Y.X.and 2042022dx0003).

摘　　要：The mammary gland is a dynamic organ that undergoes significant changes at multiple stages of postnatal development.Although the roles of systemic hormones and microenvironmental cues in mammary homeostasis have been extensively studied,the influence of neural signals,particularly those from the sympathetic nervous system,remains poorly understood.Here,using a mouse mammary gland model,we delved into the regulatory role of sympathetic nervous signaling in the context of mammary stem cells and mammary development.Our findings revealed that depletion of sympathetic nerve signals results in defective mammary development during puberty,adulthood,and pregnancy,accompanied by a reduction in mammary stem cell numbers.Through in vitro three-dimensional culture and in vivo transplantation analyses,we demonstrated that the absence of sympathetic nerve signals hinders mammary stem cell self-renewal and regeneration,while activation of sympathetic nervous signaling promotes these capacities.Mechanistically,sympathetic nerve signals orchestrate mammary stem cell activity and mammary development through the extracellular signal-regulated kinase signaling pathway.Collectively,our study unveils the crucial roles of sympathetic nerve signals in sustaining mammary development and regulating mammary stem cell activity,offering a novel perspective on the involvement of the nervous system in modulating adult stem cell function and organ development.

关 键 词：mammary development mammary stem cells sympathetic nerve mammary microenvironment 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]