膝关节消肿方治疗湿热痹阻型膝骨关节炎的临床观察  

Clinical Observation of Knee Joint Swelling Relief Prescription for Knee Osteoarthritis with Damp-Heat Impediment Type

作　　者：朱守旭 朱磊[2] 张宗逸 吴港归 ZHU Shou-xu;ZHU Lei;ZHANG Zong-yi;WU Gang-gui(Anhui University of Traditional Chinese Medicine,Hefei 230038,China;The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230032,China)

机构地区：[1]安徽中医药大学,安徽合肥230038 [2]安徽中医药大学第一附属医院,安徽合肥230032

出　　处：《云南中医中药杂志》2024年第12期31-35,共5页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：全国名中医传承工作室建设项目(czbkjf20200037);安徽省级中医优势专科项目(zyyfw20220126)。

摘　　要：目的探究膝关节消肿方治疗湿热痹阻型膝骨关节炎的临床疗效。方法将60例早期膝骨关节炎患者随机分为治疗组和对照组,2组各30例。治疗组采取中药膝关节消肿方内服,对照组采取盐酸氨基葡萄糖片口服,经过4周的治疗,观察并比较2组患者的临床疗效,中医证候评分、疗效性评价量表分值(WOMAC评分和VAS评分),以及患者外周血血清中治疗前后的IL-6、TNF-α、hs-CRP数值的变化。结果治疗组总有效率为93.33%,对照组总有效率为76.67%,2组比较差异具有统计学意义(P<0.05);2组在降低中医证候评分、WOMAC评分、VAS评分评分方面优于治疗前(P<0.05),且治疗组降低程度优于对照组(P<0.05);2组患者的外周血血清中,炎症标志物IL-6、TNF-α、hs-CRP的水平在治疗后明显低于治疗前(P<0.05),且治疗组降低优于对照组(P<0.05)。结论膝关节消肿方治疗湿热痹阻型膝骨关节炎具有较好的治疗效果,可以降低患者的炎症水平、改善中医证候评分、提高病人生活质量,对于湿热痹阻型膝骨关节炎具有显著疗效。Objective:To study the clinical effect of Knee Joint Swelling Relief Prescription in the treatment of knee osteoarthritis(KOA)with damp-heat impediment type.Methods:Sixty patients with early-stage KOA were randomly divided into a treatment group and a control group,30 cases each group.The treatment group received oral administration of Knee Joint Swelling Relief Prescription and the control group was given oral glucosamine hydrochloride tablets.After four weeks of treatment,the clinical effect,TCM symptom scores,evaluation metrics(WOMAC and VAS scores),and changes in peripheral blood serum levels of IL-6,TNF-α,and hs-CRP before and after treatment were observed and compared between the groups.Results:The total effective rate was 93.33%in the treatment group compared to 76.67%in the control group,with a statistically significant difference(P<0.05).Both groups showed significant improvements in TCM symptom scores,WOMAC,and VAS scores after treatment(P<0.05),with greater improvements observed in the treatment group(P<0.05).Serum levels of inflammatory markers IL-6,TNF-α,and hs-CRP were significantly reduced after treatment in both groups(P<0.05),with more pronounced reductions in the treatment group(P<0.05).Conclusion:The Knee Joint Swelling Relief Prescription demonstrates significant therapeutic effects in the treatment of KOA patients with damp-heat impediment type,and effectively reduces inflammation,improves TCM symptom scores,and enhances patients'quality of life,which offers a promising treatment for knee osteoarthritis with damp-heat impediment.

关 键 词：膝骨关节炎 湿热痹阻 膝关节消肿方 

分 类 号：R684.3[医药卫生—骨科学]