基于数据挖掘探讨治疗妇科血证的中成药用药规律  

Exploration of Prescription Patterns of Chinese Patent Medicines forTreating Gynecological Blood Disorders Based on Data Mining

作　　者：张远芳 李涛 张旨蓉 左晓静 杨丽娟 ZHANG Yuan-fang;LI Tao;ZHANG Zhi-rong;ZUO Xiao-jing;YANG Li-juan(Yunnan University of Traditional Chinese Medicine,Kunming 650500,China;Traditional Chinese Medicine Hospital of Xundian County,Kunming 655200,China)

机构地区：[1]云南中医药大学,云南昆明650500 [2]寻甸县中医医院,云南昆明655200

出　　处：《云南中医中药杂志》2024年第12期54-61,共8页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

基　　金：云南省科技厅中医药联合专项资助项目(2021010001-182)。

摘　　要：目的通过数据挖掘分析治疗妇科血证的中成药处方信息,探索其组方规律及核心类方,以期为临床用药及新药研发提供思路与参考。方法筛选整理2020年版《中华人民共和国药典》(一部以下简称《中国药典》)、《新编国家中成药》中所收载治疗妇科血证的中成药处方信息,运用中医传承计算平台系统(V3.5)对其进行方剂分析、关联规则分析与聚类分析。结果共筛选出137个处方,通过统计分析得出主治疾病以崩漏最多,以气血两虚证、气滞血瘀证为主,以补气养血、活血化瘀为主要治疗原则;共计使用中药294味,累计使用频次达1565次,当归的使用频率最高,药性以温性为主,药味多用甘苦,药物归经多归肝脾肾经,补虚药在药物功效中使用最多。通过关联规则分析,得出关联药对数据24条,核心药物组合19组,通过聚类分析,得出核心类方5个。结论利用中医传承计算平台分析治疗妇疗妇科血证的中成药组方规律、核心类方可为临床应用和新药研发提供依据。Objective:To analyze the prescription information of Chinese patent medicines used in treating gynecological blood disorders through data mining,and explore prescription patterns and core prescriptions to provide insights and references for clinical application and new medicine development.Methods:Prescription information for treating gynecological blood disorders was extracted from the 2020 edition of the Pharmacopoeia of the People's Republic of China(Volume I)and the Newly Compiled National Chinese Patent Medicines.By using TCM Inheritance Computing Platform(V3.5),formula analysis,association rule analysis,and cluster analysis were performed.Results:A total of 137 prescriptions were included.Statistical analysis revealed that uterine bleeding was the most common indication,primarily associated with Qi-blood deficiency and Qi stagnation with blood stasis.The main therapeutic principles were tonifying Qi to nourish blood as well as promoting blood circulation to resolve stasis.A total of 294 herbs were used 1,565 times in total,with Angelica being the most frequently used.The property of most herbs were primarily warm in nature,with sweet and bitter flavors,and commonly targeted the liver,spleen,and kidney meridians.Tonifying herbs were the most frequently employed.The association rule analysis identified 24 herb pairs,19 core herb combinations,and the cluster analysis yielded five core prescription patterns.Conclusion:The analysis of the prescription patterns and core prescriptions of Chinese patent medicines for gynecological blood disorders by using TCM Inheritance Computing Platform provides valuable guidance for clinical application and new herb development.

关 键 词：妇科血证 中成药 数据挖掘 中医传承计算平台 聚类分析 关联规则 

分 类 号：R271[医药卫生—中医妇科学]