Medication patterns of ancient Chinese medicinal prescriptions fordiabetic retinopathy  

作　　者：XIAO Li WANG Ying PENG Jun HU Shujuan PENG Qinghua YAN Junfeng 肖莉;王莹;彭俊;胡淑娟;彭清华;晏峻峰(School of Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;School of Informatics,Hunan University of Chinese Medicine,Changsha 410208,China;The First Afiliated Hospital of Hunan University of Chinese Medicine,Changsha 410208,China;Graduate school,Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;AI TCM Lab Hunan,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]School of Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China [2]School of Informatics,Hunan University of Chinese Medicine,Changsha 410208,China [3]The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410208,China [4]Graduate school,Hunan University of Chinese Medicine,Changsha 410208,China [5]Hunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China [6]AI TCM Lab Hunan,Hunan University of Chinese Medicine,Changsha 410208,China

出　　处：《World Journal of Integrated Traditional and Western Medicine》2024年第1期9-21,共13页世界中西医结合杂志（英文）

基　　金：supported by Research Project of Traditional Chinese Medicine in Hunan Province(No.B2023043);Scientific Research Project of Hunan Provincial Department of Education(No.22B0386);Research Fund of Hunan University of Chinese Medicine(No.2022XJZKC004).

摘　　要：Objective:To mine the medication patterns of ancient prescriptions for diabetic retinopathy(DR)from databases of traditional Chinese medicine(TCM)ancient books,and provide evidence for clinical practice and scientific research of TCM treatment for DR.Methods:The traditional library retrieval and modern data retrieval technology were combined to collect the ancient prescriptions in these databases,including the library ofHunan University ofChinese Medicine,Chinese Medical Dictionary,Duxiu,and Chaoxing Digital Library.And the TCM inheritance auxiliary platform(V3.0)was used for data mining,mainly including drug frequency analysis,medicinal property and meridian tropism analysis,efficacy analysis,correlation analysis,complex network analysis,and cluster analysis.Results:A total of 271 ancient prescriptions for the treatment of DR were collected,involving 296 drugs.The total medication frequency was 2,727.Most of them were cold and sweet drugs.The meridians primarily targeted were the liver,kidney,and spleen.The main effects of drugs were supplementing deficiency,clearing heat,releasing the exterior,inducing urination to drain dampness,pacifying liver and extinguishing wind,and circulating blood and transforming stasis.Saposhnikovia divaricata was the most frequently Chinese herbal medicine for DR in TCM ancient books.Saposhnikovia divaricata and ligusticum wallichi,saposhnikovia divaricata and notopterygium root,angelica sinensis and ligusticum wallichii were common herbal pairs.Saposhnikovia divaricata,ginseng,plantain seed,angelica sinensis,prepared rehmannia root and cassia seed constituted the core formula with the highest frequency.Conclusion:The core prescriptions for treating DR are mainly crafted from Dihuang pill,Ruiren powder,Siwu decoction,and Zhujing pill.Saposhnikovia divaricata is an important meridian-guiding medicine to open Xuanfu for DR.In clinical practice,the prescriptions should be modified according to the evolution of pathogenesis.

关 键 词：Diabetic retinopathy(DR) Traditional Chinese medicine Data mining Chinese medicine inheritance auxiliary platform Medication analysis 

分 类 号：R259[医药卫生—中西医结合] R276.7[医药卫生—中医内科学]