鸢尾素与原发性高血压合并冠心病的相关性  

Correlation of irisin and essential hypertension with coronary heart disease

作　　者：李白洁 梁红雷 范志宏[3] LI Bai-jie;LIANG Hong-lei;FAN Zhi-hong(Department of General Medicine,Linfen People’s Hospital,Linfen 041000,China;Department of Laboratory Medicine,Linfen People’s Hospital,Linfen 041000,China;Department of gerontology,Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]临汾市人民医院全科医学科,山西省临汾市041000 [2]临汾市人民医院检验科,山西省临汾市041000 [3]山西医科大学第二医院老年医学科

出　　处：《中国心血管病研究》2024年第12期1074-1078,共5页Chinese Journal of Cardiovascular Research

基　　金：山西省科技攻关项目(20130313017-9)。

摘　　要：目的探讨血清鸢尾素与原发性高血压(EH)合并冠心病(CHD)的关系。方法选取2022年8月至2023年10月于临汾市人民医院全科医学科确诊的EH患者50例(EH组),以及经冠状动脉造影结果确诊的EH合并CHD患者50例(EH+CHD组),同期选择性别、年龄均相匹配的健康体检者50例作为对照组。检测空腹血糖(FPG)、血脂、尿酸、酶联免疫吸附试验(ELISA)法测定血清鸢尾素水平。结果EH+CHD组和EH组血清鸢尾素水平明显低于对照组[15.73(13.46,17.59)pg/ml比18.18(16.67,21.56)pg/ml,Z=-3.497、P=0.00;16.37(15.30,18.63)pg/ml比18.18(16.67,21.56)pg/ml,Z=-2.24,P=0.025];与单纯EH组相比,EH+CHD组血清irisin水平显著降低(Z=-2.011,P=0.044)。EH患者血清鸢尾素与低密度脂蛋白胆固醇(LDL-C)、Gensini评分呈负相关(r=-0.269,P=0.038;r=-0.388,P=0.034)。二元logistic回归分析显示,鸢尾素是CHD的独立保护因素(OR=0.702,95%CI 0.540~0.913,P=0.008),年龄、尿酸是CHD的独立危险因素(OR=1.078,95%CI 1.003~1.157,P=0.040);(OR=1.014,95%CI 1.005~1.023,P=0.002)。结论血清鸢尾素与EH及CHD密切相关,鸢尾素水平降低可能参与高血压合并CHD的发生、发展。Objective To investigate the relationship between serum irisin and essential hypertension with coronary heart disease(CHD).Methods Fifty patients diagnosed with simple essential hypertension(EH group)and another fify patients diagnosed with essential hypertension combined with CHD confirmed by coronary angiography(EH+CHD group)at the Department of General Medicine of Linfen People’sHospital from August 2022 to October 2023 were recruited,and fifty cases of healthy gender and age matched subjects were selected as the normal control group.The fasting plasma glucose(FPG),blood lipid,uric acid were measured.The serum irisin level was determined by enzyme-linked immunosorbent assay(ELISA).Results The serum irisin levels were significantly decreased in the EH with CHD and EH groups compared to the normal control group[15.73(13.46,17.59)vs.16.37(15.30,18.63)vs.18.18(16.67,21.56)pg/ml,Z=-3.497,-2.24,P=0.00,0.025],and it was lower obviously in the EH with CHD group than in the simple EH group(Z=-2.011,P=0.044).The irisin level was negatively correlated with low density lipoprotein cholesterol(LDL-C)and Gensini score(r=-0.269,P=0.038;r=-0.388,P=0.034).Irisin was the independent protective factors for CHD(OR=0.702,95%CI 0.540-0.913,P=0.008);age、uric acid was the independent risk factor for CHD(OR=1.078,95%CI 1.003-1.157,P=0.040);(OR=1.014,95%CI 1.005-1.023,P=0.002).Conclusion The level of serum irisin exhibits a strong association with both EH and CHD,and the reduced levels of irisin may play a significant role in the pathogenesis and progression of essential hypertension with CHD.

关 键 词：鸢尾素 原发性高血压 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]