益气养血法预防实体瘤化疗所致骨髓抑制的队列研究  

A queue study on prevention of chemotherapy-induced myelosuppression in solid tumor patients using qi-invigorating and blood-nourishing therapy

作　　者：何文婷 左森 轩艳红 张洪亮 胡兰 张彤[3] HE Wenting;ZUO Sen;XUAN Yanhong;ZHANG Hongliang;HU Lan;ZHANG Tong(Department of Oncology,Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital,Urumqi 830000,China;Fourth Clinical Medical College,Xinjiang Medical University,Urumqi 830000,China;Department of Oncology,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]新疆维吾尔自治区中医医院肿瘤二科,乌鲁木齐830000 [2]新疆医科大学第四临床医学院,乌鲁木齐830000 [3]中国中医科学院西苑医院肿瘤科,北京100091

出　　处：《科技导报》2024年第21期132-138,共7页Science & Technology Review

基　　金：中国临床肿瘤学会齐鲁肿瘤研究基金项目(Y-Q2017-074)。

摘　　要：采用前瞻性队列研究,收集初治的实体瘤化疗患者,将“是否在化疗期间连续至少4周期联合益气养血类中药”作为暴露因素分为2组,比较骨髓抑制发生率。结果显示,暴露组3~4级中性粒细胞减少、2级及以上血小板减少、2级及以上贫血的发生率明显低于非暴露组,差异均有统计学意义(P<0.001、P=0.002、P=0.007)。研究结果证明,化疗期间联合使用益气养血法为治则的汤剂、中成药可显著降低骨髓抑制的发生率。益气养血法可作为实体瘤化疗所致骨髓抑制的预防措施,在辨证论治的基础上前移至预防阶段与化疗同步使用。Myelosuppression is one of the most common adverse reactions of chemotherapy,which leads to dose reduction,delays,or even interruptions of the treatment.This study adopted a prospective cohort design to collect data from chemotherapynaive patients with solid tumors.Patients were divided into two groups based on whether they continuously used Qi-invigorating and blood-nourishing traditional Chinese medicine(TCM)formulas for at least four cycles during the chemotherapy.The incidence rates of myelosuppression were compared between the two groups.Results showed that the incidence rates of grade 3~4 neutropenia,grade 2 or higher thrombocytopenia,and grade 2 or higher anemia were significantly lower in the exposure group compared to the non-exposure group,with all differences being statistically significant(P<0.001,P=0.002,P=0.007,respectively).The study demonstrated that the concurrent use of TCM formulas and patent medicines based on the principles of Qi-invigorating and blood-nourishing during chemotherapy can significantly reduce the incidence of myelosuppression.Qiinvigorating and blood-nourishing therapy can be used as a preventive measure for chemotherapy-induced myelosuppression in solid tumors,applied simultaneously with chemotherapy as a preventive strategy based on syndrome differentiation.

关 键 词：益气养血法 化疗 骨髓抑制 预防 队列研究 

分 类 号：R273[医药卫生—中西医结合]