刺五加苷B对快动眼睡眠剥夺模型大鼠学习记忆能力的影响  

Effect of Eleutheroside B on the Learning and Memory Ability of Rats with Rapid Eye Movement Sleep Deprivation

作　　者：张博 张可兴 侯立强[1] 关辉[2] 叶晓楠 朱珊珊 ZHANG Bo;ZHANG Kexing;HOU Liqiang;GUAN Hui;YE Xiaonan;ZHU Shanshan(The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang,China 150040;Heilongjiang Provincial Hospital,Harbin,Heilongjiang,China 150040)

机构地区：[1]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150040 [2]黑龙江省医院,黑龙江哈尔滨150040

出　　处：《中国药业》2024年第24期55-58,共4页China Pharmaceuticals

基　　金：黑龙江省卫生健康委科研课题[20210202040313]。

摘　　要：目的探讨刺五加苷B对快动眼睡眠剥夺模型大鼠学习记忆能力的影响。方法采用改进多平台水环境技术复制快动眼睡眠剥夺大鼠模型。实验分为两大组,各大组又分为对照组(等体积蒸馏水)、模型组(等体积蒸馏水)和(刺五加苷B)高、中、低剂量组(80,40,20 mg/kg),各组大鼠均灌胃相应药物或蒸馏水,每日1次,连续7 d。大鼠建模同时经六角迷宫箱进行学习记忆训练及巩固训练并测试,记录寻找时间并计算寻找频率,记录错误次数并计算认知率。结果学习记忆获得方面,与模型组比较,高、中剂量组大鼠寻找时间显著缩短,错误次数显著减少,认知率显著升高(P<0.05);学习记忆巩固方面,与模型组比较,高、中、低剂量组上述指标均显著改善(P<0.05)。结论刺五加苷B对快动眼睡眠剥夺模型大鼠的学习记忆障碍有一定改善作用。Objective To investigate the effect of eleutheroside B on the learning and memory ability of rats with rapid eye movement sleep deprivation(REMSD).Methods REMSD model rats were constructed by the modified multi-platform water environment method.The rats were divided into two groups,each of which was further divided into the control group(equal volume of distilled water),the model group(equal volume of distilled water),the high-,medium-and low-dose(eleutheroside B)groups(80,40,20 mg/kg).Rats in each group were given drugs or distilled water by gavage once a day for 7 d.Learning and memory training,consolidation training and testing were conducted by a hexagonal maze box during modeling,the search time and error frequency were recorded,the search frequency and cognitive rate were calculated.Results In terms of learning and memory acquisition,compared with those in the model group,the search time significantly shortened,the error frequency significantly decreased,and the cognitive rate significantly increased in the high-and medium-dose groups(P<0.05);in terms of learning and memory consolidation,compared with those in the model group,the above indicators significantly improved in the high-,medium-and low-dose groups(P<0.05).Conclusion Eleutheroside B has a certain improvement effect on the learning and memory disorders in REMSD rats.

关 键 词：刺五加苷B 快动眼 睡眠剥夺 学习记忆 大鼠 

分 类 号：R965[医药卫生—药理学] R285[医药卫生—药学]