双歧杆菌三联活菌与多潘立酮联合艾灸治疗初诊脑梗死恢复期胃肠道功能紊乱临床评价  

Clinical Evaluation of Live Combined Bifidobacterium,Lactobacillus and Enterococcus and Domperidone Combined with Moxibustion in the Treatment of Gastrointestinal Dysfunction Induced by Newly-Diag⁃nosed Cerebral Infarction During the Recovery Period

作　　者：安娜 赵慧 狄娜 AN Na;ZHAO Hui;DI Na(Shanxi Bethune Hospital,Taiyuan,Shanxi,China 030000)

机构地区：[1]山西白求恩医院,山西太原030000

出　　处：《中国药业》2024年第24期114-117,共4页China Pharmaceuticals

基　　金：山西省吕梁市重点研发项目[2020SHFZ89]。

摘　　要：目的探讨双歧杆菌三联活菌、多潘立酮联合艾灸治疗初诊脑梗死恢复期患者胃肠道功能紊乱的临床效果。方法选取医院2021年8月至2024年4月收治的脑梗死恢复期并发胃肠道功能紊乱患者242例,按随机数字表法分为对照组和观察组,各121例。两组患者均予多潘立酮片及双歧杆菌三联活菌胶囊口服,观察组选择双侧足三里穴、肝腧穴、肾腧穴加予艾灸治疗,两组均持续治疗4周。结果观察组总有效率为96.69%,显著高于对照组的92.56%(P<0.05)。与对照组比较,观察组患者治疗后的双歧杆菌、乳杆菌显著增多,肠杆菌、肠球菌显著减少,胃泌素、胃动素、总蛋白、白蛋白水平显著升高,胃肠道症状分级量表各项目评分均显著降低(P<0.05)。结论双歧杆菌三联活菌、多潘立酮联合艾灸可改善初诊脑梗死恢复期胃肠道功能紊乱患者肠道菌群结构及胃肠道症状。Objective To investigate the clinical efficacy of live combined Bifidobacterium,Lactobacillus and Enterococcus and domperidone combined with moxibustion in the treatment of gastrointestinal dysfunction induced by newly-diagnosed cerebral infarction during the recovery period.Methods A total of 242 patients experiencing gastrointestinal dysfunction during the recovery period of cerebral infarction admitted to the hospital from August 2021 to April 2024 were selected and divided into the control group and the observation group by the random number table method,with 121 cases in each group.The patients in the two groups were given Domperidone Tablets and Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules,Oral,on this basis,the patients in the observation group were given moxibustion on the bilateral Zusanli,Ganshu and Shenshu acupoints.Both groups were treated for four weeks.Results The total effective rate in the observation group was 96.69%,which was significantly higher than 92.56%in the control group(P<0.05).Compared with those in the control group,the Bifidobacterium and Lactobacillus counts significantly increased in the observation group after treatment,Enterobacter and Enterococcus counts significantly decreased,gastrin(GAS),motilin(MTL),total protein(TP),and albumin(Alb)levels significantly increased,the scores of various items on the Gastrointestinal Symptom Rating Scale(GSRS)significantly decreased(P<0.05).Conclusion Live combined Bifidobacterium,Lactobacillus and Enterococcus and domperidone combined with moxibustion can improve the intestinal flora structure and gastrointestinal symptoms in patients with gastrointestinal dysfunction induced by newly-diagnosed cerebral infarction during the recovery period.

关 键 词：艾灸 双歧杆菌三联活菌胶囊 初诊 脑梗死 恢复期 胃肠道功能紊乱 临床疗效 

分 类 号：R969.4[医药卫生—药理学]