自拟补气益肾活血方联合小针刀治疗早中期股骨头坏死患者的临床疗效  

Clinical effect of self-designed Buqi Yishen Huoxue Prescription combined with small needle knife on the early-stage and middle-stage osteonecrosis of the femoral head

作　　者：建展展 牛清波 郭志华 JIAN Zhan-zhan;NIU Qing-bo;GUO Zhi-hua

机构地区：[1]郑州中医骨伤病医院骨关节科,河南郑州450000 [2]郑州中医骨伤病医院微创骨科,河南郑州450000

出　　处：《中国疗养医学》2025年第1期52-55,共4页Chinese Journal of Convalescent Medicine

摘　　要：目的探索自拟补气益肾活血方联合小针刀治疗早中期股骨头坏死(ONFH)患者的临床疗效。方法选取郑州中医骨伤病医院2022年1月至2024年1月收治的早中期ONFH患者为研究对象,共120例,随机数字表分为松解术组和联合组。松解术组60例行基于经筋理论下小针刀治疗,联合组60例增加自拟补气益肾活血方,12周后,对比两组髋关节镇痛疗效、髋关节活动度、血管舒缩因子表达水平、不良反应。结果两组治疗12周后视觉模拟评分法(VAS)评分较治疗前降低,联合组低于松解术组(P<0.05);两组治疗前Harris髋关节功能评分比较差异无统计学意义(P>0.05);联合组治疗12周后Harris髋关节功能评分优于松解术组(P<0.05)。两组治疗12周后髋关节各活动方向的活动度水平较治疗前升高,联合组高于松解术组(P<0.05)。两组治疗1周后组胺(HIS)、内皮素(ET-1)、去甲肾上腺素(NE)水平较治疗前降低,联合组低于松解术组;一氧化氮(NO)水平较治疗前升高,联合组高于松解术组(P<0.05)。经Fisher确切概率法检验,联合组不良反应发生率5.00%(3/60)与松解术组8.33%(5/60)比较,差异无统计学意义(P>0.05)。结论早中期ONFH患者应用自拟补气益肾活血方联合小针刀治疗,可改善其血管舒缩因子表达,调节髋关节活动度,提高髋关节镇痛疗效,安全性良好。Objective To explore the clinical effect of self-designed Buqi Yishen Huoxue Prescription combined with small needle knife on the early-stage and middle-stage osteonecrosis of the femoral head(ONFH).Methods A total of 120 patients with early-stage and middle-stage ONFH admitted to Zhengzhou Hospital for Bone Injury and Illness of Traditional Chinese Medicine from January 2022 to January 2024 were selected as the study objects.They were divided into the release operation group and the combination group by random number table method.After 12 weeks,the analgesic efficacy,hip motion,vasomotor factor expression level and adverse events of the two groups were compared.Results After 12 weeks of treatment,the visual analogue scale(VAS)score of the two groups was significantly lower than that before treatment,which was significantly lower in the combination group than the release operation group(P<0.05).There was no significant difference in the Harris hip scale(HHS)scores between the two groups before treatment(P>0.05).After 12 weeks of treatment,the HHS score was significantly better in the combination group than the release operation group(P<0.05).After 12 weeks of treatment,the motion level of hip joint in all directions was significantly higher than that before treatment,which was significantly higher in the combination group than the release operation group(P<0.05).After 1 week of treatment,the levels of histamine(HIS),endothelin(ET-1)and norepinephrine(NE)in the two groups were significantly lower than those before treatment,and the level of nitric oxide(NO)was significantly higher,which were more pronounced in the combination group than the release operation group(P<0.05).By Fisher's exact probability test,there was no significant difference in the incidence of adverse events between groups(5.00%[3/60]VS 8.33%[5/60],P>0.05).Conclusion In patients with early-stage and middle-stage ONFH,self-designed Buqi Yishen Huoxue Prescription combined with small needle knife can improve the expression of vasomotor factors,regu

关 键 词：补气益肾活血方 小针刀 股骨头坏死 血管舒缩因子 

分 类 号：R274.9[医药卫生—中西医结合]