1例头孢他啶致重度血小板减少患者的药学监护  

Pharmaceutical Care of Severe Thrombocytopenia Possibly Caused by Ceftazidime:A Case Report

作　　者：吴紫娟[1] 王珂杰 金姿 蔡晓辉[4] 王康[1] WU Zi-juan;WANG Ke-jie;JIN Zi;CAI Xiao-hui;WANG Kang(Department of Pharmacy,Changzhou Second People′s Hospital,Changzhou 213100,China;Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,China;Department of Pharmacy,Jiaze Health Center,Wujin District,Changzhou 213152,China;Hematology Department of Changzhou Second People′s Hospital,Changzhou 213100,China)

机构地区：[1]常州市第二人民医院药学部,江苏常州213100 [2]陕西省中医药大学,陕西咸阳712046 [3]常州市武进区嘉泽卫生院药剂科,江苏常州213152 [4]常州市第二人民医院血液科,江苏常州213100

出　　处：《海峡药学》2024年第11期111-114,共4页Strait Pharmaceutical Journal

基　　金：2023年常州市第四批科技计划项目(应用基础研究指导性)-常州四药基金(基金编号:CJ20239015)。

摘　　要：1例71岁女性,因“发现皮肤瘀斑、口腔出血、重度血小板减少”急诊入院。完善相关检验检查及骨髓穿刺,排除了引起血小板减少的常见原因。临床药师在药学监护时了解到患者近期有抗感染药物使用史,遂联系患者的家庭药师,调阅近期的就诊及用药记录,并进行循证分析,提出患者重度血小板减少可能与抗感染药物“头孢他啶”相关。治疗上予以丙种球蛋白、甲泼尼龙冲击治疗,联合使用促血小板生成素、输注血小板等升血小板治疗。5天后患者血小板恢复正常,顺利出院。One 71-year-old female Patient was admitted to the emergency department for “detected skin spots,oral bleeding and severe thrombocytopenia”.Relevant tests and bone marrow puncture were improved to exclude the common causes of thrombocytopenia.The clinical pharmacist learned that the patient had a recent history of anti-infectious drugs,so he contacted the patient′s family doctor to review the recent treatment and medication records,and conducted evidence-based analysis,suggesting that the patient′s severe thrombocytopenia might be related to the anti-infectious drug “ceftazidime”.On treatment,gamma globulin and methylprednisolone were treated,and ascending platelet treatment such as thrombopoietin and platelet transfusion were jointly used.Five days later,the patient returned to normal platelets and was discharged smoothly.

关 键 词：头孢他啶 血小板减少 药学监护 药物不良反应 

分 类 号：R969[医药卫生—药理学]