对碳青霉烯类抗菌药物相关不良反应自发报告的分析  

Analysis of Spontaneous Reports on Adverse Reactions Related to Carbapenem Antibacterial Drugs.

作　　者：陈志达 蔡晓芳 徐凤丹 CHEN Zhi-da;CAI Xiao-fang;XU Feng-dan(Quality and Technical Review and Monitoring Evaluation Center,Zhangzhou 363000,China;Zhangpu Hospital,Zhangpu 363200,China)

机构地区：[1]漳州市质量技术评审与监测评价中心,福建漳州363000 [2]漳州市漳浦县医院,福建漳浦363200

出　　处：《海峡药学》2024年第11期118-121,共4页Strait Pharmaceutical Journal

摘　　要：目的 了解碳青霉烯类抗菌药物不良反应情况与特点,为临床安全用药提供参考。方法 调取我市2020年1月至2023年12月该类药物相关不良反应自发报告并进行回顾性分析。结果 162份有效碳青霉烯类抗菌药物不良反应报告来自11家医疗机构,涉及亚胺培南、美罗培南、厄他培南和阿比培南这四种药物及11个系统/器官。一般ADR85例,严重ADR96例(有些患者发生的不良反应不止一种表现形式)。常见ADR为神经系统和消化系统,老人与10岁以下儿童较常见,ADR多在用药后三天内发生,严重ADR可致住院时间延长。结论 临床使用此类药物应明确用药指征,肾功能不全者应调整剂量或间隔,有中枢神经系统疾病者慎用,特殊人群尤其老年与10岁以下患者要注意ADR发生,且加强用药前三天监测。OBJECTIVE To comprehend the situation and characteristics of adverse reactions associated with carbapenem antibacterial drugs,and to provide a reference for safe clinical drug use.METHODS Spontaneous adverse reaction reports pertaining to this drug type,collected from January 2020 to December 2023 in our city,were retrieved and subjected to retrospective analysis.RESULTS A total of 162 valid adverse reaction reports of carbapenem antibacterial drugs were received from 11 medical institutions,encompassing four drugs:imipenem,meropenem,ertapenem,and biapenem,affecting 11 systems/organs.There were 85 cases of general ADR and 96 cases of severe ADR.Common ADRs were observed in the nervous and digestive systems.The elderly and children under 10 years of age were more susceptible.ADRs typically occurred within three days of medication administration.Severe ADRs could lead to prolonged hospital stays.CONCLUSION In clinical use of these drugs,clear indications for drug use should be established.For patients with renal insufficiency,adjustments to the dose or interval should be made.Caution should be exercised when administering to those with central nervous system diseases.Special populations,particularly elderly patients,should be vigilant in monitoring the occurrence of ADRs and strengthen monitoring during the initial three days of medication.

关 键 词：碳青霉烯 不良反应 分析 

分 类 号：R969[医药卫生—药理学]