腹膜透析联合血液透析治疗终末期肾病的效果  

Effect of Peritoneal Dialysis Combined with Hemodialysis in the Treatment of End-stage Renal Disease

作　　者：彭婷 PENG Ting(Mianyang Central Hospital,Mianyang 621000,China)

机构地区：[1]绵阳市中心医院,四川绵阳621000

出　　处：《中外医学研究》2024年第34期5-9,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究腹膜透析联合血液透析治疗终末期肾病的效果。方法:选取2021年6月—2022年12月绵阳市中心医院收治的60例终末期肾病患者。根据随机数表法将其分为对照组和观察组,各30例。对照组实施腹膜透析治疗,观察组在对照组基础上实施血液透析治疗。比较两组临床疗效,治疗前后肾功能指标、炎症因子及免疫指标、生存质量。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血肌酐(Scr)、血尿素氮(BUN)、24 h尿蛋白水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、CD8^(+)均低于对照组,CD4^(+)高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组精神健康、社会功能、一般健康、生理职能、精力、躯体功能、情感功能及生理功能评分均高于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(χ^(2)=11.429,P<0.05)。结论:终末期肾病患者通过腹膜透析联合血液透析治疗,可提升其临床效果,并发症发生率低。Objective:To study the effect of peritoneal dialysis combined with hemodialysis in the treatment of end-stage renal disease.Method:A total of 60 patients with end-stage renal disease admitted to Mianyang Central Hospital from June 2021 to December 2022.According to the random number table method,they were divided into a control group and an observation group,with 30 cases in each group.The control group received peritoneal dialysis treatment,while the observation group received hemodialysis treatment on the basis of the control group.The clinical efficacy,renal function indicators,inflammatory factors and immune indicators,and quality of life before and after treatment were compared of two groups.Result:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of serum creatinine(Scr),blood urea nitrogen(BUN),and 24-hour urinary protein in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),and CD8^(+)in the observation group were lower than those in the control group,while CD4^(+)was higher than that in the control group,the differences were statistically significant(P<0.05).After treatment,the observation group had higher scores in mental health,social function,general health,physiological function,energy,physical function,emotional function,and physiological function than the control group,and the differences were statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(χ^(2)=11.429,P<0.05).Conclusion:Patients with end-stage renal disease can be treated with peritoneal dialysis combined with hemodialysis to improve their clinical outcomes and reduce the incidence of complications.

关 键 词：腹膜透析 血液透析 终末期肾病 临床疗效 不良反应 

分 类 号：R692.5[医药卫生—泌尿科学]