麻杏石甘汤加减对慢性阻塞性肺疾病急性加重期患者的影响  

Effect of Modified Maxing Shigan Decoction on Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients

作　　者：叶翔扬 陈靖楠 上官坤常 YE Xiangyang;CHEN Jingnan;SHANGGUAN Kunchang(Anxi Hospital of Traditional Chinese Medicine,Anxi 362400,China;不详)

机构地区：[1]安溪县中医院,福建安溪362400

出　　处：《中外医学研究》2024年第34期148-152,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析麻杏石甘汤加减对慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的影响。方法:选取2021年1月—2023年6月安溪县中医院呼吸与危重症医学科收治的100例AECOPD患者作为研究对象,按照随机数表法将患者分为对照组与研究组,各50例。对照组实施常规西医治疗,研究组在对照组基础上实施麻杏石甘汤加减治疗,两组均治疗14 d。比较两组肺功能指标、动脉血气指标、血清炎症指标、中医症候评分、治疗效果。结果:治疗14 d后,两组第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))、最大呼气流量(peak expiratory flow,PEF)、FEV_(1)/用力肺活量(forced vital capacity,FVC)高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。治疗14 d后,两组(partial pressure of oxygen,PaO_(2))、血氧饱和度(arterial oxyhemoglobin saturation,SaO_(2))高于治疗前,二氧化碳分压(partial pressure of carbon dioxide,PaCO_(2))低于治疗前,且研究组治疗14 d后PaCO_(2)低于对照组,差异有统计学意义(P<0.05);但两组治疗14 d后PaO_(2)、SaO_(2)比较,差异无统计学意义(P>0.05)。治疗14 d后,两组C反应蛋白(C-reactive protein,CRP)、降钙素原(procalcitonin,PCT)及中医症候评分低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论:麻杏石甘汤加减有利于改善AECOPD患者呼吸功能和治疗效果,减轻炎症反应,缓解临床症状。Objective:To analyze the effect of modified Maxing Shigan Decoction on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients.Method:A total of 100 patients with AECOPD who admitted to the Department of Respiratory and Critical Care Medicine of Anxi Hospital of Traditional Chinese Medicine from January 2021 to June 2023 were selected as the research objects,the patients were divided into the control group and the study group according to the random number table method,with 50 cases in each group.The control group was given routine western medicine treatment,the study group was treated with modified Maxing Shigan Decoction on the basis of the control group,and two groups were treated for 14 d.The pulmonary function indexes,arterial blood gas indexes,serum inflammatory indexes,traditional Chinese medicine symptom score and treatment effect were compared between two groups.Result:After 14 d of treatment,the forced expiratory volume in one second(FEV_(1)),peak expiratory flow(PEF),FEV_(1)/forced vital capacity(FVC)in two groups were higher than those before treatment,and those in the study group were higher than the control group,the differences were statistically significant(P<0.05).After 14 d of treatment,the partial pressure of oxygen(PaO_(2))and arterial oxyhemoglobin saturation(SaO_(2))in two groups were higher than those before treatment,and the partial pressure of carbon dioxide(PaCO_(2))were lower than those before treatment,PaCO_(2) in the study group after 14 d of treatment was lower than that in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in PaO_(2) and SaO_(2) between the two groups after 14 d of treatment(P>0.05).After 14 d of treatment,the C-reactive protein(CRP),procalcitonin(PCT)and traditional Chinese medicine symptoms scores in two groups were lower than those before treatment,and those in the study group were lower than the control group,the differences were statistically significant(P<0.05).The total effect

关 键 词：麻杏石甘汤加减 慢性阻塞性肺疾病急性加重期 呼吸功能 炎症指标 影响 

分 类 号：R259[医药卫生—中西医结合]