淫羊藿及其主要活性成分改善男性不育症的作用机制研究进展  

Research Progress of Epimedium in the Treatment of Male Infertility

作　　者：唐田 谭天阳 刘柘君 白雪 TANG Tian;TAN Tianyang;LIU Zhejun;BAI Xue(Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment of Major Disease,Beijing 100700,China;Beijing Institute of Genomics,Chinese Academy of Sciences/China National Center for Bioinformation,Beijing 100101,China;Rehabilitation Medicine Department,Xiyuan Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100091,China;School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China)

机构地区：[1]中国中医科学院医学实验中心,北京市中医药防治重大疾病基础研究重点实验室,北京100700 [2]中国科学院北京基因组研究所,北京100101 [3]中国中医科学院西苑医院康复医学科,北京100091 [4]首都医科大学中医药学院,北京100069

出　　处：《中国药物警戒》2024年第11期1238-1242,共5页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(82304767);中央级公益性科研院所基本科研业务费专项基金(JJPY2022021、ZZ15-YQ-055);中国中医科学院科技创新工程项目(CI2021B017);中国中医科学院西苑医院院级师承项目(YJMPSC202437)。

摘　　要：目的评估淫羊藿及其主要活性成分在治疗男性不育症中的潜力,探讨其在中医药治疗中的应用前景。方法通过系统文献回顾,分析淫羊藿及其主要活性成分在改善精子生成、保护睾丸微环境、调节性激素水平、抗氧化应激及改善性功能障碍等方面的作用。结果淫羊藿及其主要活性成分显示出通过调节关键信号通路和改善细胞凋亡来保护生殖细胞的潜力,同时在改善性功能障碍方面也显示出积极效果。结论淫羊藿的活性成分在治疗男性不育症方面具一定的潜力,未来研究应进一步验证其临床疗效,以促进其在男性生殖健康领域的应用。Objective To assess the potential of Epimedium and its active components in the treatment of male infertility and to explore their prospects in traditional Chinese medicine therapy.Methods A systematic literature review was conducted to analyze the significant effects of Epimedium and its main active components on improving spermatogenesis,protecting the testicular microenvironment,regulating sex hormone levels,combating oxidative stress,and alleviating sexual dysfunction.Results Epimedium demonstrated the potential to protect germ cells by modulating key signaling pathways and improving apoptosis,and it also showed positive effects in improving sexual dysfunction.Conclusion The active components of Epimedium have significant potential in the treatment of male infertility.Future research should further verify their clinical efficacy to promote their application in the field of male reproductive health.

关 键 词：男性不育 淫羊藿 活性成分 机制 生殖 精子生成 抗氧化应激 

分 类 号：R917[医药卫生—药物分析学]