注射用头孢曲松钠致儿童免疫性溶血性贫血2例分析  

Two Cases of Ceftriaxone Sodium for Injection Induced Immune Hemolytic Anemia in Children

作　　者：丁邑强 吕志英 刘沧海 温琴琴 方小平 DING Yiqiang;LYU Zhiying;LIU Canghai;WEN Qinqin;FANG Xiaoping(Department of Pharmacy,Xingguo Hospital Affiliated to Gannan Medical University,Xingguo Jiangxi 342400,China;Department of Blood Transfusion,Xingguo Hospital Affiliated to Gannan Medical University,Xingguo Jiangxi 342400,China;Department of Pediatric Intensive Care,Xingguo Hospital Affiliated to Gannan Medical University,Xingguo Jiangxi 342400,China;Department of Pediatrics,Xingguo Hospital Affiliated to Gannan Medical University,Xingguo Jiangxi 342400,China)

机构地区：[1]赣南医科大学附属兴国医院药剂科,江西兴国342400 [2]赣南医科大学附属兴国医院输血科,江西兴国342400 [3]赣南医科大学附属兴国医院小儿重症医学科,江西兴国342400 [4]赣南医科大学附属兴国医院儿科,江西兴国342400

出　　处：《中国药物警戒》2024年第11期1306-1308,共3页Chinese Journal of Pharmacovigilance

基　　金：赣州市卫生健康委员会科研计划项目(GZWJW-202402389)。

摘　　要：目的探讨头孢曲松致儿童免疫性溶血性贫血的临床特征、发生机制及临床救治。方法结合文献分析2例注射用头孢曲松钠致儿童免疫性溶血性贫血不良反应的发生机制和相关性。结果经关联性分析,2例患儿溶血性贫血均为头孢曲松钠所致,均予立即停药,经输血、糖皮质激素治疗后痊愈出院。结论临床实践中应重视头孢曲松致免疫性溶血性贫血不良反应发生风险,快速识别及适当的免疫学诊断和治疗有助于患者转归。Objective To explore the clinical characteristics and mechanism of adverse drug reactions caused by ceftriaxone in children with immune hemolytic anemia.Methods Two cases of ceftriaxone sodium induced adverse reactions in children with immune hemolytic anemia and the correlations with adverse reactions were analyzed.Results Correlation analysis showed that both cases of hemolytic anemia were caused by ceftriaxone sodium,which was immediately discontinued and the patients were discharged after blood transfusion and glucocorticoid treatment.Conclusion Clinicians should pay attention to the risk of adverse reactions of ceftriaxone-induced immune hemolytic anemia in clinical practice.Rapid identification and appropriate immunological diagnosis and treatment can facilitate the prognosis of patients.

关 键 词：头孢曲松 免疫性溶血性贫血 腹痛 过敏性休克 药品不良反应 抗头孢曲松抗体 血清学检测 儿童 

分 类 号：R978[医药卫生—药品] R994.11[医药卫生—药学]