吲达帕胺片致急性呼吸窘迫综合征1例分析  

One Case of Acute Respiratory Distress Syndrome Caused by Indapamide Tablets

作　　者：骆宇琛 弓清梅[1] 徐钰行 秦树琴 张囝 LUO Yuchen;GONG Qingmei;XU Yuhang;QIN Shuqin;ZHANG Jian(Department of Critical Care Medicine,the Fifth Clinical Medical College,Shanxi Medical University,Taiyuan Shanxi 030012,China;Taiyuan China Railway 17th Bureau Central Hospital,Taiyuan Shanxi 030012,China;Emergency Department of Hejin People’s Hospital,Hejin Shanxi 043300,China)

机构地区：[1]山西医科大学附属山西省人民医院重症医学科,山西太原030012 [2]中铁十七局集团有限公司中心医院重症医学科,山西太原030012 [3]河津市人民医院急诊科,山西河津043300

出　　处：《中国药物警戒》2024年第11期1312-1314,共3页Chinese Journal of Pharmacovigilance

摘　　要：目的探讨吲达帕胺引起的罕见并发症,为临床治疗提供指导。方法分析1例服用吲达帕胺致急性呼吸窘迫综合征(ARDS)的病例,通过国内外文献分析对此不良反应的发病机制、临床表现、治疗等进行讨论。结果此患者经无创呼吸机辅助通气、抗感染、升压、补液等对症治疗后,氧合改善,胸部CT好转出院。但目前对于吲达帕胺致急性呼吸窘迫综合征的具体机制尚不清楚,未来仍需进一步研究明确其发病机制。结论吲达帕胺常见的不良反应为低钾血症、低钠血症及电解质失衡等,应警惕吲达帕胺致ARDS的罕见不良反应。Objective To call attention to rare complications caused by indapamide so as to provide references for clinical treatment.Methods One case of acute respiratory distress syndrome(ARDS)attributed to indapamide intake was reported.The pathogenesis,clinical manifestations,and treatment of this adverse reaction were analyzed bases on domestic and foreign literature.Results After symptomatic treatments including non-invasive ventilatory support,anti-infection therapy,vasopressor therapy,and hydration therapy,the patient’s oxygenation improved,and the chest CT scan showed favorable progression,leading to discharge.However,the underlying mechanism by which indapamide triggered ARDS had yet to be elucidated,so more research was needed to discern its pathogenesis.Conclusion While hypokalemia,hyponatremia,and electrolyte imbalances are commonly reported adverse reactions of indapamide,it is crucial to be vigilant to the rare but potential risks of ARDS associated with its use.

关 键 词：急性肺损伤 急性呼吸窘迫综合征 吲达帕胺 过敏反应 不良反应 

分 类 号：R994.11[医药卫生—毒理学] R983.1[医药卫生—药学]