前胡的一般概况及质量形成因素浅析  

Introduction and Quality Factors of Peucedanum Praeruptorum Dunn

作　　者：李耀磊[1,2] 金红宇 魏锋[1,2] 马双成 LI Yaolei;JIN Hongyu;WEI Feng;MA Shuangcheng(Institute for Control of Chinese Traditional Medicine and Ethnic Medicine,National Institutes for Food and Drug Control,Beijing 102488,China;State Key Laboratory of Drug Regulatory Science,Beijing 102629,China;Chinese Pharmacopoeia Commission,Beijing 100061,China)

机构地区：[1]中国食品药品检定研究院中药民族药检定所,北京102629 [2]药品监管科学全国重点实验室,北京102629 [3]国家药典委员会,北京100061

出　　处：《中国药物警戒》2024年第11期1315-1320,共6页Chinese Journal of Pharmacovigilance

基　　金：国家重点研发计划(2022YFC3501505,2023YFC-3504100);国家药品监督管理局药品监管科学体系建设重点项目(RS2024Z006)。

摘　　要：目的系统阐述前胡药用的历史、化学成分、药理药效、产区分布、市场需求及质量控制等内容,为前胡药材的进一步开发利用和质量控制的提升提供参考。方法依据现有研究报道,系统梳理前胡药用历史沿革及其关键化学成分分布特征,阐述在现代化学和药理学理论基础下,前胡的传统药效与现代药理效用特征。结合文献,对前胡药材的道地产区、主要种植地域、市场需求量及产量进行全面分析。在此基础上,综合探讨前胡的标准现状及质量情况,并分析其质量的主要影响因素。结果前胡药用历史悠久且药理活性丰富,简单香豆素、呋喃香豆素、吡喃香豆素是其主要化学成分,浙江、安徽、江西为前胡药材主要道地产区,在重庆、贵州等地均有大规模种植。目前市场上以家种和仿野生品为主,野生资源逐渐变少。白花前胡乙素是其质量评价不合格的主要原因;白花前胡甲素和白花前胡乙素2个指标显示,环境地理、抽薹、不同形态等是影响前胡质量的主要因素。结论本文分析前胡药材多个方面,揭示了其基本概况及质量形成因素,对于推动前胡药材的可持续利用和产业发展具有一定意义。Objective To describe the history of the medicinal use of Peucedanum Praeruptorum Dunn(PD),its chemical composition,efficacy,areas of production,market demands and quality control and to provide reference for its development,utilization and quality control.Methods Based on the reports available,the medicinal use of PD and its key chemical constituents were traced,and the traditional and modern pharmacology of PD was elaborated in terms of chemistry and pharmacology.The areas of production,chief planting areas,market demands and production of PD were analyzed.The current standard for PD and problems with the quality were discussed.Results PD had a long history of medicinal use and plenty of pharmacological activities,whose chemical components included simple coumarin,furan coumarin and pyranocoumarin.Zhejiang,Anhui and Jiangxi were important areas of production of PD.There was largescale cultivation in Chongqing,Guizhou and elsewhere.The current market was dominated by domestic species and simulated wild products,and the wild resources were diminishing.The main reason for defects of the product was the presence of Praeruptorin B.Analysis of Praeruptorin A and Praeruptorin B suggested that environmental geography,extraction,and different morphologies made a huge difference to the quality of PD.Conclusion The basic profile and determinants of quality of PD have been explored.It is of great significance to promote the sustainable use and industrial development of the plant.

关 键 词：前胡 质量评价 白花前胡甲素 白花前胡乙素 简单香豆素 呋喃香豆素 质量标准 道地产区 

分 类 号：R93[医药卫生—生药学]