脉络膜血管生物标志物在糖尿病性黄斑水肿中的应用研究进展  

Research progress of choroidal vascular biomarkers in diabetic macular edema

作　　者：李雪 景蕊霞 王振 周娜 LI Xue;JING Ruixia;WANG Zhen;ZHOU Na(Graduate Department of Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250117,China;Department of Ophthalmology,Affiliated Hospital of Gansu Medical College,Pingliang 744000,China;Department of Ophthalmology,Central Hospital Affiliated to Shandong First Medical University,Jinan 250013,China;Department of Clinical Laboratory,Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250001,China)

机构地区：[1]山东第一医科大学(山东省医学科学院)研究生部,山东济南250117 [2]甘肃医学院附属医院眼科,甘肃平凉744000 [3]山东第一医科大学附属中心医院眼科,山东济南250013 [4]山东第一医科大学附属省立医院检验科,山东济南250001

出　　处：《山东第一医科大学（山东省医学科学院）学报》2024年第12期764-768,共5页Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences

基　　金：山东省自然科学基金(ZR2023MH157)。

摘　　要：糖尿病性黄斑水肿(diabetic macular edema,DME)是糖尿病性视网膜病变(diabetic retinopathy,DR)的一种表现,可以发生在DR的任何阶段,是导致DR患者视力丧失最常见的原因之一。脉络膜血管是黄斑中心凹唯一的血供来源,其结构改变会损害视网膜功能。常用的脉络膜生物学标志物包括中心凹下脉络膜厚度(subfoveal choroidal thickness,SFCT)、脉络膜血管指数(choroidal vascularity index,CVI)。SFCT和CVI反映了脉络膜血管的变化情况,尤其是CVI,在监测DME进展、评估预后等方面拥有巨大的应用前景。深入理解基线脉络膜特征以及抗血管内皮生长因子(vascular endothelial growth factor,VEGF)治疗后脉络膜血管的变化,对于评估DME的治疗效果和疾病预后具有重要的指导意义。Diabetic macular edema(DME)is a manifestation of diabetic retinopathy(DR),which can occur at any stage of DR and is one of the most common causes of vision loss in patients with DR.The choroid is the only source of blood supply to the macular fovea,so choroidal abnormalities can damage retinal function.The commonly used choroidal biomarkers are subfoveal choroidal thickness(SFCT)and choroidal vascularity index(CVI).SFCT and CVI reflect the choroidal blood flow,especially CVI,which has a great application prospect in monitoring the progress of DME and evaluating the prognosis.Understanding the baseline choroidal characteristics and the changes of choroidal vessels after anti-vascular endothelial growth factor(VEGF)treatment has important guiding significance for evaluating the therapeutic effect and prognosis of DME.

关 键 词：糖尿病性黄斑水肿 抗血管内皮生长因子 中心凹下脉络膜厚度 脉络膜血管指数 

分 类 号：R587.2[医药卫生—内分泌] R774.5[医药卫生—内科学]