系统性红斑狼疮中医辨证分型与可溶性黏附分子、炎性因子的相关性研究  

Study on the correlation between TCM syndrome differentiation and soluble adhesion molecules and inflammatory factors in SLE

作　　者：赵丽秦 肖梦星 刘冬梅 ZHAO Liqin;XIAO Mengxing;LIU Dongmei(Clinical laboratory,Meixian People's Hospital,Meixian Shaanxi 722300,China;Medical laboratory,Xi'an Gaoling District Hospital,Xi'an Shaanxi 710200,China)

机构地区：[1]眉县人民医院检验科,陕西眉县722300 [2]西安市高陵区医院医学检验科,陕西西安710200

出　　处：《四川中医》2024年第12期14-17,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探究系统性红斑狼疮中医辨证分型与可溶性黏附分子、炎性因子的相关性。方法:选取2020年5月~2023年6月期间于我院就诊的系统性红斑狼疮患者218例进行研究,收集患者一般信息及中医四诊资料,统计中医证型分布情况,比较不同证型患者基本资料、疾病活动指数、血清可溶性黏附分子及炎性因子水平差异,采用Pearson相关性分析探究不同中医辨证分型与血清可溶性黏附分子及炎性因子水平的关系。结果:纳入218例患者中医证型构成:肝肾阴虚证60例、脾肾阳虚证66例、热毒炽盛证92例。系统性红斑狼疮疾病活动指数(SLEDAI)评分、血清可溶性细胞间黏附分子1(sICAM-1)、血管内皮细胞黏附分子1(sVCAM-1)水平在不同证型中均呈现肝肾阴虚组<脾肾阳虚组<热毒炽盛组趋势(P<0.05);不同证型患者血清γ-干扰素(IFN-γ)、肿瘤坏死因子α(TNF-α)、白介素10(IL-10)表达水平比较,热毒炽盛组TNF-α水平高于脾肾阳虚组(P<0.05),两组IFN-γ、TNF-α、IL-10水平均高于肝肾阴虚组(P<0.05),热毒炽盛组IFN-γ、IL-10水平与脾肾阳虚组比较,差异不具有统计学意义(P>0.05);Pearson相关性分析显示不同中医辨证分型SLEDAI评分与血清sICAM-1、sVCAM-1、IFN-γ、TNF-α、IL-10均呈现正相关(P<0.05)。结论:系统性红斑狼疮不同中医辨证分型与可溶性黏附分子、炎性因子存在着一定的相关性,对患者血清相关可溶性黏附分子及炎症指标进行检测,可作为中医辨证的辅助工具,有利于诊断价值的提升。Objective:To explore the relationship between TCM dialectical classification of systemic lupus erythematosus and soluble adhesion molecules and inflammatory factors.Methods:A total of 218patients with systemic lupus erythematosus who were treated in our hospital from May 2020to June 2023were selected for this study.According to the dialectical classification of traditional Chinese medicine,they could be divided into liver and kidney Yin deficiency group,spleen and kidney Yang deficiency group and heat toxicity intense group.The differences of basic data,disease activity index,serum soluble adhesion molecules and inflammatory factors among patients with different syndrome types were compared.Pearson correlation analysis was used to explore the relationship between different TCM dialectical types and serum levels of soluble adhesion molecules and inflammatory factors.Results:In 218patients,60cases of liver and kidney Yin deficiency,66cases of spleen and kidney Yang deficiency,and 92cases of heat and toxin incandescence were included.There were significant differences in SLEDAI scores among different TCM syndrome differentiation types,liver and kidney Yin deficiency grouP<spleen and kidney Yang deficiency grouP<heat toxicity blazing group(P<0.05);The serum levels of soluble intercellular adhesion molecule-1(sICAM-1)and vascular endothelial cell adhesion molecule-1(sVCAM-1)in different TCM syndrome differentiation types were significantly different,and the levels of both were liver and kidney Yin deficiency grouP<spleen and kidney Yang deficiency grouP<heat toxicity intense group(all P<0.05).The expression levels of γ-interferon(IFN-γ),tumor necrosis factorα(TNF-α)and interleukin-10(IL-10)in serum of patients with different TCM syndrome differentiation types were different,and the level of TNF-αin heat toxicity incandescating group was higher than that in spleen-kidney Yang deficiency group(P<0.05).The levels of IFN-γ,TNF-αand IL-10in 2groups were higher than those in liver-kidney Yin deficiency group(P<0.05),

关 键 词：系统性红斑狼疮 中医辨证分型 炎性因子 可溶性黏附分子 

分 类 号：R593.241[医药卫生—内科学]