大柴胡汤合当归芍药散联合艾灸神阙穴治疗肾病综合征的疗效及TGF-β/Smad信号通路的影响  

Efficacy of Dacaihu Decoction combined with DangguiShaoyao Powder combined with moxibustion Shenque point in the treatment of nephrotic syndrome and influence on TGF-β/Smad signaling pathway

作　　者：徐大琳 廖天平 付璐 陈天和 XU Dalin;LIAO Tianping;FU Lu(Department of Nephrology,Yilong County General Hospital,Yilong Sichuan 637600,China)

机构地区：[1]仪陇县总医院肾内科,四川仪陇637600

出　　处：《四川中医》2024年第12期106-108,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探讨大柴胡汤合当归芍药散联合艾灸神阙穴治疗肾病综合征(NS)的疗效及对转化生长因子-β(TGF-β)/Smad信号通路的影响。方法:选取2023年3月~2024年3月本院收治的124例肾病综合征患者为研究对象,根据随机数表法分为艾灸组、综合组,各62例。艾灸组采用艾灸神阙穴治疗,综合组采用大柴胡汤合当归芍药散联合艾灸神阙穴治疗,比较两组治疗效果、肾功能、免疫功能及TGF-β/Smad信号通路蛋白表达。结果:综合组治疗总有效率为96.77%,高于艾灸组的85.48%(P<0.05);治疗后综合组24h尿蛋白排泄率(UAER)、血尿氮素(BUN)、肾损伤分子1(KIM-1)、血肌酐(Scr)低于艾灸组(P<0.05);治疗后综合组TGF-β、Smad2、Smad3、基质金属蛋白酶抑制因子-1(TIMP-1)低于艾灸组,E-钙黏蛋白(E-cadherin)高于艾灸组(P<0.05);治疗后综合组辅助性T淋巴细胞17(Th17)、Th17/调节性T细胞(Treg)、CD8+低于艾灸组,Treg、CD4+、CD4+/CD8+高于艾灸组(P<0.05)。结论:大柴胡汤合当归芍药散联合艾灸神阙穴治疗NS可以显著提高患者临床治疗效果,抑制TGF-β/Smad信号通路激活,改善患者免疫功能,提高肾功能。Objective:To investigate the therapeutic effect of Dachaihu Decoction combined with DangguiShaoyao Powder and moxibustion Shenque point in the treatment of nephrotic syndrome(NS)and the effect on transforming growth faction-β(TGF-β)/Smad signaling pathway.Methods:124patients with nephrotic syndrome admitted to our hospital from March 2023to March 2024were selected as the study objects,and were divided into moxibustion group and comprehensive group according to random number table method,with 62cases each.Moxibustion group was treated with moxibustion Shenque point,and comprehensive group was treated with Dachaihu Decoction combined with DangguiShaoyao Powder combined with moxibustion Shenque point.The therapeutic effect,renal function,immune function and TGF-β/Smad signaling pathway protein expression were compared between the two groups.Results:The total effective rate of comprehensive group was 96.77%,which was higher than that of moxibustion group 85.48%(P<0.05).Urinary protein excretion rate(UAER),urinary nitrogen(BUN),renal injury molecule 1(KIM-1)and serum creatinine(Scr)in the comprehensive group were lower than those in the moxibustion group(P<0.05).After treatment,TGF-β,Smad2,Smad3and matrix metalloproteinase-1(TIMP-1)in comprehensive group were lower than those in moxibustion group,and E-cadherin was higher than those in moxibustion group(P<0.05).After treatment,helper T lymphocyte 17(Th17),Th17/regulatory T cells(Treg)and CD8+were lower than those in moxibustion group,and Treg,CD4+and CD4+/CD8+were higher than those in moxibustion group(P<0.05).Conclusion:Dachaihu Decoction combined with DangguiShaoyao Powder combined with moxibustion Shenque point in the treatment of NS can significantly improve the clinical therapeutic effect of patients,inhibit the activation of TGF-β/Smad signaling pathway,improve the immune function of patients and enhance renal function.

关 键 词：大柴胡汤合当归芍药散 艾灸神阙穴 肾病综合征 转化生长因子-β/Smad 

分 类 号：R692[医药卫生—泌尿科学]