益肾解毒汤联合血液透析治疗慢性肾衰竭的效果及对肾功能、氧化应激、微炎症反应的影响  

Effect of Yishen Jiedu Decoction combined with hemodialysis in the treatment of chronic renal failure and the influence on renal function,oxidative stress and micro-inflammatory response

作　　者：马习习 王晓星[1] 刘贤亮[1] 张小敏[1] 马崇宇 MA Xixi;WANG Xiaoxing;LIU Xianliang(Department of Nephrology,Lu'an Hospital of Traditional Chinese Medicine,Lu'an Anhui 237000,China)

机构地区：[1]六安市中医院肾内一科,安徽六安237000

出　　处：《四川中医》2024年第12期114-116,共3页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察益肾解毒汤联合血液透析(HD)治疗慢性肾衰竭(CRF)的效果及对肾功能、氧化应激、微炎症反应的影响。方法:选取2021年12月~2023年12月我院收治的90例CRF患者,以随机数表法分为对照组与观察组,各45例。给予对照组患者HD治疗,观察组在此基础上给予益肾解毒汤治疗。比较两组临床疗效、治疗前后中医证候评分、肾功能[血尿素氮(BUN)、血肌酐(Scr)]、氧化应激[超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)]、微炎症反应[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)]水平,统计治疗期间不良反应的发生情况。结果:观察组治疗总有效率为88.89%,高于对照组的71.11%,且中医证候评分较对照组低(P<0.05)。治疗1个月后两组BUN、Scr、MDA、CRP、TNF-α、IL-6水平均降低,观察组较对照组低(P<0.05);SOD、GSH-Px水平较治疗前增加,观察组较对照组高(P<0.05)。治疗期间两组不良反应发生率比较差异不显著(P>0.05)。结论:益肾解毒汤联合HD治疗CRF患者的效果确切,能有效改善患者临床症状、肾功能及氧化应激状态,同时有助于缓解微炎症反应,具有较高的安全性。Objective:To observe the effect of Yishen Jiedu Decoction combined with hemodialysis(HD)in the treatment of chronic renal failure(CRF)and the influence on renal function,oxidative stress and micro-inflammatory response.Methods:Ninety patients with CRF admitted to the hospital from December 2021to December 2023were selected,and divided into a control group and an observation group by random number table method,with 45cases in each group.Patients in the control group were treated with HD,and patients in the observation group were treated with Yishen Jiedu Decoction on this basis.The two groups were compared on clinical effects,traditional Chinese medicine syndrome scores,renal function[blood urea nitrogen(BUN)and serum creatinine(Scr)],oxidative stress[superoxide dismutase(SOD),malondialdehyde(MDA)and glutathione peroxidase(GSH-Px)],and micro-inflammatory response[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)]before and after treatment.The incidence rates of adverse reactions were calculated.Results:The total response rate of the observation group(88.89%)was higher than that of the control group(71.11%),and traditional Chinese medicine syndrome scores were lower than those of the control group(P<0.05).After 1month of treatment,the levels of BUN,Scr,MDA,CRP,TNF-α,and IL-6in the two groups were reduced.The levels in the observation group were lower than those in the control group(P<0.05).The levels of SOD and GSH-Px were higher than those before treatment,and the levels in the observation group were higher than those in the control group(P<0.05).The incidence rates of adverse reactions in the two groups were comparable(P>0.05).Conclusion:Yishen Jiedu Decoction combined with HD is effective in the treatment of patients with CRF,which can effectively improve clinical symptoms,renal function and oxidative stress,and help to alleviate micro-inflammatory response,with high safety.

关 键 词：益肾解毒汤 血液透析 慢性肾衰竭 肾功能 氧化应激 微炎症反应 

分 类 号：R692.5[医药卫生—泌尿科学]