中药干预细胞焦亡防治妇科病的研究进展  

The research progress of traditional Chinese medicine interfering with cellular pyroptosis to prevent gynecological diseases

作　　者：陈颖庆 邓阿黎[1,2] 姜惠中[2] 熊梦欣 王莹[1] 郭高帅 CHEN Yingqing;DENG Ali;JIANG Huizhong(Hubei University of Traditional Chinese Medicine,Wuhan Hubei 430061,China;Hubei Provincial Hospital of Traditional Chinese Medicine,Hubei University of Traditional Chinese Medicine,Wuhan Hubei 430074,China)

机构地区：[1]湖北中医药大学,湖北武汉430061 [2]湖北中医药大学附属湖北省中医院,湖北武汉430074

出　　处：《四川中医》2024年第12期214-220,共7页Journal of Sichuan of Traditional Chinese Medicine

基　　金：姜惠中全国名中医传承工作室(国中医药办人教函[2022]245号);湖北省自然科学基金(编号:2023AFD132)。

摘　　要：细胞焦亡(Pyroptosis)是一种新型Gasdermin(GSDM)家族蛋白依赖性程序性死亡方式,与炎症反应密切相关,参与多种疾病发生,在机体免疫应答中起重要作用。研究发现细胞焦亡与妇科病如盆腔炎症性疾病、复发性流产、子宫内膜异位症、早发性卵巢功能不全以及卵巢癌有密切联系。细胞焦亡相对于女性生殖系统疾病是一把双刃剑,一方面可以释放细胞内容物来放大炎症,增加细菌对抗生素耐药性;另一方面可以抑制异位子宫内膜细胞、卵巢癌细胞生长,增强化疗药物的敏感性,增强治疗效果。近年来,中医药通过调节细胞焦亡治疗妇科病的研究逐渐增多,疗效显著。因此该文总结了细胞焦亡与妇科病发生发展的关系,并归纳中药活性成分和中药复方干预细胞焦亡治疗妇科相关疾病的研究,为探索妇科病发病机制及中医药治疗提供新思路。Pyroptosis is a novel Gasdermin(GSDM)family protein-dependent programmed death mode,which is closely related to inflammatory response,involved in many diseases,and plays an important role in the body's immune response.Pyroptosis has been found to be strongly associated with gynecological diseases such as pelvic inflammatory disease,recurrent spontaneous abortion,endometriosis,premature ovarian insufficiency,and ovarian cancer.Pyroptosis is a double-edged sword compared to female reproductive system diseases.On the one hand,it can release cell contents to amplify inflammation and increase antibiotic resistance;on the other hand,it can inhibit the growth of ectopic endometrial cells and ovarian cancer cells,enhance the sensitivity of chemotherapy drugs,and enhance the therapeutic effect.In recent years,the research of traditional Chinese medicine(TCM)in treating gynecological diseases by regulating pyroptosis has been gradually increasing with remarkable efficacy.Therefore,the review summarizes the relationship between pyroptosis and the development of gynecological diseases,and summarizes the research on the intervention of active ingredients of TCM and TCM compound in the treatment of gynecological related diseases,in order to provide a new way of thinking for exploring the pathogenesis of gynecological diseases and the treatment of TCM.

关 键 词：细胞焦亡 盆腔炎 复发性流产 子宫内膜异位症 早发性卵巢功能不全 卵巢癌 中医药 

分 类 号：R271[医药卫生—中医妇科学]