基于磁共振血管壁成像分析颈动脉易损斑块的危险因素  

Analysis of risk factors for vulnerable carotid plaques based on magnetic resonance vascular wall imaging

作　　者：项良旭 李美英[1] 凤兆海[1] 徐竞[1] XIANG Liangxu;LI Meiying;FENG Zhaohai;XU Jing(Maanshan People’s Hospital,Maanshan 243000,China)

机构地区：[1]马鞍山市人民医院,安徽马鞍山243000

出　　处：《中国实用神经疾病杂志》2024年第12期1465-1470,共6页Chinese Journal of Practical Nervous Diseases

基　　金：马鞍山市人民医院青年科研基金项目(编号:YQ-2022-10)。

摘　　要：目的利用磁共振血管壁成像技术分析颈动脉易损斑块的危险因素。方法回顾性纳入2021-10—2023-06就诊于马鞍山市人民医院并经颈动脉彩超确诊的颈动脉粥样斑块患者114例,根据磁共振血管壁成像结果分为易损斑块组65例和稳定斑块组49例,分析2组患者的临床资料及外周血检查结果,采用二分类多因素Logistic回归方法分析易损斑块的危险因素。结果单因素分析发现年龄、中性粒细胞与淋巴细胞比值(NLR)、纤维蛋白原与白蛋白比值(FAR)、纤维蛋白原和白蛋白是颈动脉易损斑块的危险因素,差异均有统计学意义(P<0.05)。多因素Logistic回归模型显示,患者年龄越大出现易损斑块的概率越大(OR=1.054,95%CI:1.002~1.108),中性粒细胞百分比越大出现易损斑块的概率越大(OR=1.052,95%CI:1.009~1.098),白蛋白值越高出现易损斑块的概率越小(OR=0.846,95%CI:0.754~0.948)。结论年龄、NLR、FAR、纤维蛋白原和白蛋白是颈动脉易损斑块的危险因素,早期发现和干预易损斑块可减少脑卒中的发生。Objective To analyze the risk factors for carotid artery vulnerable plaques using magnetic resonance vessel wall imaging.Methods Totally 114 patients with carotid atherosclerotic plaques diagnosed by carotid ultrasound in Maanshan People’s Hospital from October 2021 to June 2023 were retrospectively included,and were divided into the vulnerable plaques group with 65 cases and the stable plaques group with 49 cases according to the results of magnetic resonance vascular wall imaging,and the clinical data and the results of peripheral blood tests were analyzed.The risk factors for vulnerable plaques were analyzed by binary multifactorial Logistic regression method.Results Univariate analysis revealed that age,neutrophil to lymphocyte ratio(NLR),fibrinogen to albumin ratio(FAR),fibrinogen and albumin were risk factors for carotid artery vulnerable plaques,and the differences were statistically significant(P<0.05).Multifactorial Logistic regression modeling showed that the probability of vulnerable plaque was greater with older age(OR=1.054,95%CI:1.002-1.108),greater neutrophil percentage was greater with vulnerable plaque(OR=1.052,95%CI:1.009-1.098),and greater albumin values were less likely to be vulnerable plaque(OR=0.846,95%CI:0.754-0.948).Conclusion Age,NLR,FAR,fibrinogen,and albumin are risk factors for carotid artery vulnerable plaques,and early detection and intervention of vulnerable plaques can reduce the incidence of stroke.

关 键 词：动脉粥样硬化 易损斑块 炎症 中性粒细胞与淋巴细胞比值 纤维蛋白原与白蛋白比值 

分 类 号：R544.2[医药卫生—心血管疾病]