Gathering scientific evidence for a new bioactive natural ingredient:The combination between chemical profiles and biological activities of Flueggea virosa extracts  

作　　者：Gokhan Zengin Stefano Dall’Acqua Kouadio Ibrahime Sinan Abdullahi Ibrahim Uba Stefania Sut Gregorio Peron Ouattara Katinan Etienne Manoj Kumar Carlos L.Cespedes-Acuna Julio Alarcon-Enos Adriano Mollica Mohamad Fawzi Mahomoodally 

机构地区：[1]Department of Biology,Science Faculty,Selcuk University,Konya,Turkey [2]Department of Pharmaceutical and Pharmacological Sciences,University of Padova,Via Marzolo 5,35131 Padova,Italy [3]Department of Molecular Biology and Genetics,Faculty of Engineering and Natural Sciences,Kadir Has University,Istanbul,34083,Turkey [4]Laboratoire de Botanique,UFR Biosciences,Universite Felix Houphouet-Boigny,Abidjan,Republic of Cote d’Ivoire [5]Chemical and Biochemical Processing Division,ICAR-Central Institute for Research on CottonTechnology,Mumbai,400019,India [6]Plant Biochemistry and Phytochemical Ecology Lab,Departmento de Ciencias Basicas,Facultad de Ciencias,Universidad del Bio Bio,Av.Andres Bello#720,Chillan,Chile [7]Department of Pharmacy,University“G.d’Annunzio”of Chieti-Pescara,66100,Chieti,Italy [8]Department of Health Sciences,Faculty of Medicine and Health Sciences,University of Mauritius,Reduit,80837,Mauritius

出　　处：《Food Bioscience》2022年第5期1254-1264,共11页食品生物科学（英文）

摘　　要：Flueggea virosa (Roxb. ex Willd.) Royle is a plant with several traditional uses in tropical countries. To study the potential usefulness, extracts from stem barks and leaves of F. virosa were obtained with different solvents. The phytochemical composition was assessed using LC-MS and NMR. Triterpenes, as oleanolic (0.05-88.09 mg/g extract), and ursolic (0.03-94.36 mg/g extract) acids were determined. In addition, ellagic and gallic acid derivatives were present in large concentrations in some of the extracts. Antioxidant (radical scavenging, reduction ability, and metal chelating) and enzyme inhibitory (cholinesterase, tyrosinase, amylase, and glucosidase) effects were assessed by in vitro chemical assays. The methanol extracts and infusions from both parts show higher antioxidant ability when compared with ethyl acetate extracts, and the antioxidant capacity was correlated with the total phenolic contents of the tested extracts. The extracts demonstrate enzyme inhibitory abilities on AChE and BChE, and multivariate approaches allowed for correlating the activities with the presence of triterpenoids (R > 0.8). Furthermore, molecular docking was used to get insights into the interactions between the triterpenoids and the tested enzymes. Together, these results indicate that F. virosa represents a significant source of naturally-occurring bioactive compounds that can be exploited as a new ingredient for the development of novel functional products with promising biological properties.

关 键 词：Flueggea virosa TRITERPENOIDS ANTIOXIDANT Bioactive agents Antidiabetic effect 

分 类 号：O62[理学—有机化学]