Epac结构与功能及其在心血管疾病中的作用  

Structure and function of Epac and its role in cardiovascular diseases

作　　者：陈耿基 肖佳海 梁浩林 张志珍 CHEN Gengji;XIAO Jiahai;LIANG Haolin;ZHANG Zhizhen(School of Basic Medicine,Guangdong Medical University,Dongguan 523808,China;School of Medical Technology,Guangdong Medical University,Dongguan 523808,China)

机构地区：[1]广东医科大学基础医学院,东莞523808 [2]广东医科大学医学技术学院,东莞523808

出　　处：《生命的化学》2024年第12期2171-2180,共10页Chemistry of Life

摘　　要：cAMP是细胞内重要的第二信使,对细胞的分化、生长、代谢等过程产生影响。cAMP直接激活交换蛋白(Epac)是小相对分子质量GTP酶Ras超家族的鸟嘌呤核苷酸交换因子,参与cAMP调控的多种生物学过程。Epac是多结构域蛋白,包含羧基端的催化结构域和氨基端的调节结构域,有Epac1、Epac2A、Epac2B和Epac2C四种不同亚型。Epac通过不同的信号转导过程参与炎症反应、抗氧化、抗凋亡、细胞增殖与分化以及钙离子的调节等。近年来的研究显示,Epac与心力衰竭、心律失常、动脉粥样硬化以及缺血-再灌注损伤有着密切联系,可作为心血管疾病新的治疗靶点。本文介绍了Epac的结构特点、激活过程与生理功能,并概述了Epac在心血管疾病发生发展中的作用。cAMP is an important second messenger within cells,which affecting the processes such as cellular differentiation,growth and metabolism.Exchange protein directly activated by cAMP(Epac),a guanine nucleotide exchange factors of small molecular weight GTPase Ras family,is involved in diverse biological processes regulated by cAMP.Epac is a multidomain protein that contains a catalytic domain at the carboxyl terminal and a regulatory domain at the amino terminal.There are four different subtypes of Epac:Epac1 and Epac2A,Epac2B,Epac2C.Epac signaling participates in inflammatory response,antioxidant and antiapoptosis,cell proliferation and differentiation,and calcium ion regulation.Recent studies have shown that Epac is closely related to heart failure,arrhythmia,atherosclerosis and ischemia-reperfusion injury,which can be used as a new therapeutic target for cardiovascular diseases.This paper introduces the structural characteristics,activation process,and physiological function of Epac,and summarizes its role in the occurrence and development of cardiovascular diseases.

关 键 词：Epac CAMP 信号转导 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]