外泌体在特应性皮炎中的研究进展  

Research Advances of Exosomes in Atopic Dermatitis

作　　者：宋佳园 李鑫[1] 王建国[1] SONG Jiayuan;LI Xin;WANG Jianguo(Hunan University of Chinese Medicine,Hunan 410208,China)

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《中国皮肤性病学杂志》2024年第12期1400-1404,共5页The Chinese Journal of Dermatovenereology

基　　金：湖南省教育厅科学研究重点项目(22A0280);湖南省中医药管理局科学研究项目(C2023015)。

摘　　要：特应性皮炎(atopic dermatitis,AD)是由免疫系统紊乱引起的慢性炎症性皮肤病,强烈的瘙痒严重影响患者生活质量。外泌体是机体细胞分泌的一种细胞外囊泡,发挥细胞间通讯、靶向调节免疫反应等作用。新近研究发现,外泌体不仅参与AD的病理过程,而且在诊断与治疗中有独特价值,具有成为AD相关药物递送载体的前景。本文总结了外泌体在AD诊断、致病机制和治疗等方面的进展,并展望未来外泌体在AD中研究的发展方向和前景,以期探索外泌体诊断及治疗AD的可能性,为AD的临床诊治提供新方向。Atopic dermatitis(AD)is a chronic inflammatory skin disease caused by the disturbance of immune system,The intense pruritus affects the life quality of the patients.Exosomes are a kind of extracellular vesicles released by cells and play the functions in cell-to-cell communication and targeted regulation of immune response.Recent studies have found that exosomes not only participate in the pathological process of AD,but also play unique roles in the diagnosis and treatment of AD.Exosomes have the potential of becoming AD-related drug delivery vehicles.This review intends to summarize the research progress of exosomes in the diagnosis,pathogenesis and treatment of AD,and to provide new directions for the clinical application of exosomes in the diagnosis and treatment of AD.

关 键 词：外泌体 特应性皮炎 新型生物标志物 致病机制 治疗策略 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]