miR-214在动物生殖生理调控中的功能和机制  

Research Progress on Function and Mechanism of miR-214 in Regulation of Animal Reproductive Physiology

作　　者：王娟红 常卫华 WANG Juanhong;CHANG Weihua(College of Animal Science,Xichang University,Xichang 615013,China;Laboratory for Testing and Prevention of Animal Diseases in Panxi Region,Xichang 615013,China;Key Laboratory of Local Characteristic Goat in Sichua,Xichang 615013,China)

机构地区：[1]西昌学院动物科学学院,四川西昌615013 [2]四川攀西动物疫病检测与防控实验室,四川西昌615013 [3]四川地方特色山羊重点实验室,四川西昌615013

出　　处：《中国兽医杂志》2024年第12期111-117,共7页Chinese Journal of Veterinary Medicine

基　　金：国家自然基金地区项目(32360905);中国农业大学对口支援西昌学院联合基金项目(ZXL202403,2024TC080)。

摘　　要：微小核糖核酸(miRNA)是一类非编码核糖核酸(RNA),在生物体的各种生理过程中发挥重要的调控作用。微小核糖核酸214(miR-214)作为一种重要的miRNA,在动物生殖生理调控过程中具有广泛的应用和研究价值。本文对miR-214的结构,及其对生殖细胞分化、生长和凋亡的调控作用,对机体和组织器官生长发育的调控作用以及对生殖系统疾病的调控作用等方面进行了综述,并对其未来的研究进行了展望,以期为进一步探索和研究miR-214在生殖生物学中的作用及应用提供理论依据。MicroRNAs(miRNAs)are a class of non-coding RNAs that play essential regulatory roles in various physiological processes in organisms.As an important miRNA,microRNA-214(miR-214)has significant application and research value in the regulation of reproductive physiology in animals.This paper reviews the structure of miR-214,its regulatory role in the differentiation,growth,and apoptosis of reproductive cells,its influence on the growth and development of the body and tissues/organs,and its involvement in the regulation of reproductive system diseases.Additionally,the future research directions of miR-214 are discussed to provide a theoretical basis for further exploration and investigation of the roles and applications of miR-214 in reproductive biology.

关 键 词：miR-214 生殖细胞 发育 生殖系统疾病 

分 类 号：S852.21[农业科学—基础兽医学]