AE-IPF肺热络瘀证病证结合生物标志物的研究概况及应用探析  

Research Overview and Discussion of Application of AE-IPF (Lung Heat and Collateral ObstructionSyndrome) Combined with Disease and Syndrome Biomarkers

作　　者：王誉儒 王亚勤 李英杰 王琳琳[2] 臧凝子[2] 庞立健[2] WANG Yuru;WANG Yaqin;LI Yingjie;WANG Linlin;ZANG Ningzi;PANG Lijian(Graduate School of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学研究生学院,沈阳110847 [2]辽宁中医药大学附属医院,沈阳110032

出　　处：《世界科学技术-中医药现代化》2024年第8期2030-2035,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会青年科学基金项目(82004294):清络饮调控IL-6/STAT3/Lin28B/let-7d环路平衡干预炎症刺激上皮间充质转化治疗特发性肺纤维化急性加重机制研究,负责人:臧凝子;辽宁省科学技术厅创新能力提升联合基金(2022-NLTS-13-03):基于Hippo通路清络饮促进糖代谢重编程调控肺泡巨噬细胞M1/M2平衡干预AE-IPF的机制,负责人:庞立健;辽宁省人力资源和社会保障厅辽宁省“百千万人才工程”资助项目(辽人社函[2021]79号):基于TGF-β1/Smads信号传导通路的清络饮干预特发性肺纤维化急性加重细胞凋亡机制研究,负责人:庞立健。

摘　　要：特发性肺纤维化(Idiopathic pulmonary fibrosis,IPF)是一种进展性、炎症性的间质性肺疾病,临床上被分为IPF稳定期及IPF急性发作期(Acute exacerbation of idiopathic pulmonary fibrosis,AE-IPF),其在预防和治疗上都面临着巨大难题,加重了患者的健康与生活负担。目前关于AE-IPF的诊断手法都较为局限,而生物标志物安全简易且特异性强,对AE-IPF的诊断及治疗具有重要意义。本文基于AE-IPF肺热络瘀证的理论内涵,通过对病证结合生物标志物理论及其研究思路的阐释,参考已发现的可与AE-IPF肺热络瘀证相关的生物标志物,探讨AE-IPF肺热络瘀证病证结合生物标志物的应用价值,从分子水平阐释AEIPF肺热络瘀证的病机内涵,并分析病证结合生物标志物对AE-IPF肺热络瘀证的中医药临床指导作用。Idiopathic pulmonary fibrosis(IPF)is a progressive and inflammatory interstitial lung disease,clinically divided into stable and acute exacerbation periods of idiopathic pulmonary fibrosis(AE-IPF),which faces great difficulties in prevention and treatment,increasing the health and life burden of patients.At present,the diagnostic methods of AE-IPF are relatively limited,while biomarkers are safe,simple and specific,which are of great significance for the diagnosis and treatment of AE-IPF.Based on the theoretical connotation of AE-IPF(lung heat and collateral obstruction syndrome),this paper explores the application value of combining AE-IPF lung heat stagnation syndrome and biomarkers,explains the pathogenesis of AE-IPF lung heat stagnation syndrome at the molecular level,and analyzes the guiding role of combining syndromes and biomarkers in the clinical application of traditional Chinese medicine for AE-IPF lung heat stagnation syndrome.

关 键 词：特发性肺纤维化急性发作期 肺热络瘀证 病证结合 生物标志物 

分 类 号：R259[医药卫生—中西医结合]