补阳还五汤抗血栓作用及机制研究进展  

Research Progress on the Effect and Mechanism of Buyang Huanwu Decoction Against Thrombosis

作　　者：艾琳 毕倩倩 王媛 任晗归 王枫 AI Lin;BI Qianqian;WANG Yuan;REN Hangui;WANG Feng(Shanghai Seventh People’s Hospital,Shanghai 200137,China;College of Traditional Chinese Pharmacology,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海市第七人民医院,上海200137 [2]上海中医药大学中药学院,上海201203

出　　处：《世界科学技术-中医药现代化》2024年第8期2036-2046,共11页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：2023年度上海市自然科学基金面上项目(23ZR1448700):人参皂苷Rb2诱导CCR2+单核细胞自噬抗动脉粥样硬化炎性反应及易损斑块形成的作用机制研究,负责人:王枫;浦东新区科技发展基金民生科研专项(PKJ2020-Y16):人参皂苷Rg1通过PINK1/Parkin介导的线粒体自噬保护缺血损伤的机制研究,负责人:王枫。

摘　　要：补阳还五汤是治疗气虚血瘀证的经典代表方剂,被广泛用于预防或治疗心脑血管等疾病,具有良好的抗血栓前景,因此希望通过总结补阳还五汤的抗血栓作用及机制研究,为补阳还五汤治疗血栓性疾病的临床应用提供参考和依据。本文总结了近十五年来补阳还五汤抗血栓作用的研究文献,其中包括补阳还五汤抗血栓作用的临床疗效研究以及机制研究,全面概括了目前补阳还五汤抗血栓作用的研究进展,分析并探讨了补阳还五汤治疗血栓性疾病的优势与不足,并对后续研究进行展望。补阳还五汤可以有效缓解血栓性疾病患者的症状和提高患者生存预后,其作用机制主要是通过改善血液流变学指标、降低血小板功能、保护血管内皮功能、促进纤溶活性和抗炎等。补阳还五汤可以多靶点、多层次地预防和治疗血栓性疾病,具有较好的临床应用前景。Buyang Huanwu Decoction(BYHWD),a commonly used formula for treating"Qi deficiency and blood stasis"syndrome,is widely used in modern clinical medicine to prevent or treat ischemic cardia-cerebrovascular and thromboembolic diseases,etc.Therefore,this article aims to summarize the clinical research progress and related mechanisms of BYHWD in treating thrombosis,so as to provide supporting evidence and basis for its clinical application in thrombotic diseases.This article reviewed the research findings from the past fifteen years on the anti-thrombotic properties of BYHWD.It also discussed the strengths and weaknesses of BYWHD in the treatment of thrombotic diseases,offering insights into potential areas for future research.BYHWD can effectively alleviate thrombotic diseases by improving hemorheology parameters,reducing platelet function,protecting endothelial function,promoting fibrinolysis activity,and exerting anti-inflammatory effects.BYHWD can prevent and treat thrombotic diseases through multiple targets and multiple levels,making it a promising option for clinical applications.

关 键 词：补阳还五汤 抗血栓 临床疗效 作用机制 研究进展 

分 类 号：R285[医药卫生—中药学]