白细胞分类计数在甲型流感病毒感染者中的临床价值  

Clinical value of white blood cell differential count in patients with influenza A virus infection

作　　者：李波 陈炜钢[2] 杨帆[2] 骆晓凤 LI Bo;CHEN Weigang;YANG Fan;LUO Xiaofeng(Department of Clinical Laboratory,Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine(the Second Hospital of Nanjing),Nanjing,Jiangsu 210003,China;Department of Clinical Laboratory,the Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210011,China)

机构地区：[1]南京中医药大学附属南京医院(南京市第二医院)检验科,江苏南京210003 [2]南京医科大学第二附属医院检验科,江苏南京210011

出　　处：《国际检验医学杂志》2024年第S02期80-85,共6页International Journal of Laboratory Medicine

摘　　要：目的比较甲型流感患者与上呼吸道感染者白细胞计数(WBC)和分类及超敏C-反应蛋白(hs-CRP)的表达水平,并评估各项指标在鉴别诊断甲型流感病毒感染中的临床价值。方法回顾性选择2023年2月21日至3月31日来南京中医药大学附属南京医院接受治疗的患者,其中甲型流感病毒抗原阳性且同期进行血常规和hs-CRP检测的719例患者作为研究对象,流感病毒抗原阴性的上呼吸道感染者作为对照组共699例。分析不同年龄、不同性别患者的甲型流感病毒感染情况,比较甲型流感患者和上呼吸道感染者WBC及分类、中性粒细胞(NC)、淋巴细胞(LC)、中性粒细胞/淋巴细胞比值(NLR)和hs-CRP的表达水平。结果在所研究的4250例患者中,有1713例鼻咽分泌物中检测到了甲型流感抗原阳性,占40.31%。在1713例甲型流感患者中,(≤14岁)儿童甲型流感病毒的感染率明显高于(≥15~59岁)成人和(≥60岁)老年人,差异具有统计学意义(P<0.01)。不同性别之间的甲型流感感染率大致相近,差异无统计学意义(P>0.05)。甲型流感患者多以WBC和NC正常为主,三个年龄段上呼吸道感染患者其WBC和NC异常升高构成比显著高于其相应年龄段甲型流感患者,差异具有统计学意义(P<0.01)。不同年龄段的甲型流感患者其WBC分类及hs-CRP表达水平存在差异,甲型流感儿童组其hs-CRP的表达水平显著低于甲型流感成人组和老年人组。结论儿童甲型流感的感染率高于成人,且NLR、WBC、NC和hs-CRP表达水平显著低于成人组,WBC计数分类对甲型流感与上呼吸道感染的鉴别诊断具有一定的临床指导意义。Objective To compare the white blood cell count(WBC),classification,and expression levels of high-sensitivity C-reactive protein(hs-CRP)between patients with influenza A and those with upper respiratory tract infections,and to evaluate the clinical value of various indicators in the differential diagnosis of influenza A virus infection.Methods A retrospective study was conducted on 719 patients who received treatment at Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine from February 21 to March 31,2023.Among them,719 patients who were positive for influenza A virus antigen and underwent blood routine and hs-CRP testing during the same period were selected as the research subjects,and 699 upper respiratory tract infections who were negative for influenza virus antigen were selected as the control group.The infection status of influenza A virus in patients of different ages and genders were analyzed,and the expression levels of WBC and classification,neutrophils(NC),lymphocytes(LC),neutrophil/lymphocyte ratio(NLR),and hs-CRP between influenza A patients and patients with upper respiratory tract infections were compared.Results Among the 4250 patients studied,1713 cases tested positive for influenza A antigen in nasopharyngeal secretions,accounting for 40.31%.Among 1713 cases of influenza A patients,the infection rate of influenza A virus in children(≤14 years old)was significantly higher than that in adults(≥15-59 years old)and elderly(≥60 years old),and the difference was statistically significant(P<0.01).The infection rates of influenza A among different genders were roughly similar,with no statistically significant difference(P>0.05).Most patients with influenza A had normal WBC and NC,and the proportion of abnormal increase in WBC and NC in upper respiratory tract infection patients in the three age groups was significantly higher than that in their corresponding age groups of influenza A patients,and the difference was statistically significant(P<0.01).There were differences in WBC cl

关 键 词：白细胞计数 超敏C-反应蛋白 甲型流感病毒 中性粒细胞/淋巴细胞比值 

分 类 号：R511.7[医药卫生—内科学]