梅毒早期诊断中两种梅毒抗体检测方法的应用效果  

Application effect of two syphilis antibody detection methods in early diagnosis of syphilis

作　　者：周雪飞 ZHOU Xuefei(Department of Clinical Laboratory,Changping District Hospital of Traditional Chinese and Western Medicine,Beijing 102200,China)

机构地区：[1]北京市昌平区中西医结合医院检验科,102200

出　　处：《国际检验医学杂志》2024年第S02期102-105,共4页International Journal of Laboratory Medicine

摘　　要：目的探讨在梅毒早期诊断中,梅毒螺旋体颗粒凝集试验(TPPA)与甲苯胺红不加热血清反应素试验(TRUST)的应用价值。方法以该院2023年1-12月检验科接收的82例疑似梅毒患者的检测样本为研究对象,分别为其提供TPPA、TRUST检测,同时进行跟踪调查,以最终临床诊断结果为参照,了解两种方法的诊断效能。结果TRUST、TPPA阳性检出率分别为76.83%、79.27%,与临床诊断结果79.27%比较,差异均无统计学意义(P>0.05);TPPA诊断灵敏度、特异度分别为98.46%、94.12%均高于TRUST(P<0.05)。结论在梅毒早期诊断中,TRUST、TPPA均具有较高的实践价值,但TPPA的诊断灵敏度和特异度更高,可作为首选方法。Objective To explore the application value of Treponema Pallidum Particle Agglutination Test(TPPA)and Toluidine Red Unheated Serum Test(TRUST)in the early diagnosis of syphilis.Methods A total of 82 suspected syphilis patients received by Department of Clinical Laboratory in the hospital from January 2023 to December 2023 were selected as the research subjects.TPPA and TRUST tests were provided to them,and follow-up investigations were conducted to evaluate the diagnostic efficacy of the two methods based on the final clinical diagnosis results.Results The positive detection rates of TRUST and TPPA were 76.83%and 79.27%,respectively.Compared with the clinical diagnosis result of 79.27%,there was no statistically significant difference(P>0.05);The diagnostic sensitivity and specificity of TPPA were 98.46%and 94.12%,respectively,which were higher than TRUST(P<0.05).The positive detection rates of TRUST and TPPA were 76.83%and 79.27%,respectively,and which were not statistically different compared with 79.27%of the clinical diagnosis result(P>0.05).The sensitivity and specificity of TPPA diagnosis were 98.46%and 94.12%,respectively,which were higher than those of TRUST(P<0.05).Conclusion TRUST and TPPA have high practical value in the early diagnosis of syphilis,but TPPA has higher diagnostic sensitivity and specificity and can be used as the preferred method.

关 键 词：梅毒螺旋体颗粒凝集试验 甲苯胺红不加热血清反应素试验 梅毒 

分 类 号：R759.1[医药卫生—皮肤病学与性病学] R446.6[医药卫生—临床医学]