骨桥蛋白在高血压靶器官损害中的作用  

Role of osteopontin in target organ damage in hypertension

作　　者：李静仪 朱诗源 陈依璠 王志军 LI Jingyi;ZHU Shiyuan;CHEN Yifan;WANG Zhijun(Department of Cardiology,The Affiliated Hospital of North China University of Science and Technology,Tangshan 063000,China)

机构地区：[1]华北理工大学附属医院心内科,河北唐山063000

出　　处：《华北理工大学学报（医学版）》2024年第6期494-498,共5页Journal of North China University of Science and Technology：Health Sciences Edition

基　　金：河北省卫健委医学重点科研项目(编号:ZF2024198)。

摘　　要：高血压是一种全球性的重大健康问题,伴有心、脑、肾、血管等器官损害,是一种常见的慢性疾病。近年来,骨桥蛋白(OPN)作为一种多功能蛋白,被发现与高血压相关靶器官损害密切相关。本文总结了OPN在高血压靶器官损害中的最新研究进展,探讨其在血管重构、心肌纤维化和肾脏等损伤中的作用机制,以期为高血压及其并发症的预防和治疗提供新的视角与策略。Hypertension,a common chronic disease,poses a significant global health issue and is associated with damage to organs such as the heart,brain,kidneys,and blood vessels.In recent years,osteopontin(OPN),a multifunctional protein,has been found to be closely related to target organ damage in hypertension.This article summarizes the latest research progress on the role of OPN in target organ damage in hypertension and explores its mechanism of action in vascular remodeling,myocardial fibrosis,and kidney damage,aiming to provide new perspectives and strategies for the prevention and treatment of hypertension and its complications.

关 键 词：骨桥蛋白 高血压 靶器官损害 

分 类 号：R544.1[医药卫生—心血管疾病]