衰老与腹腔脏器异位脂肪沉积的相关性  

Association between aging and ectopic fat depositions in abdominal viscera

作　　者：张娜 李晓牧 ZHANG Na;LI Xiaomu(Department of Endocrinology and Metabolism,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院内分泌科,上海200032

出　　处：《中国临床医学》2024年第6期860-867,共8页Chinese Journal of Clinical Medicine

基　　金：上海市“科技创新行动计划”港澳台科技合作项目(23410760800).

摘　　要：目的探讨衰老与胰腺、肝脏、肾脏和脾脏脂肪沉积之间的相关性。方法纳入40例研究对象,采集空腹静脉血并完成腹部3T磁共振扫描。通过Dixon-VIBE序列量化器官脂肪分数(fat fraction,FF),并测定糖代谢、脂代谢以及肝肾功能相关生化指标。采用Pearson相关性分析评估各变量间相关性,用偏相关分析调整混杂因素。结果胰腺脂肪分数(pancreatic fat fraction,PFF)与年龄独立正相关,与体质量指数(body mass index,BMI)非独立正相关(P<0.05);肝脏脂肪分数(liver fat fraction,LFF)与BMI独立正相关,与年龄非独立正相关(P<0.05);肾脏脂肪分数(kidney fat fraction,KFF)与年龄、BMI均非独立正相关(P<0.05)。PFF与LFF、KFF独立正相关(P<0.05);调整PFF后,LFF与KFF不存在相关性。PFF与空腹C肽(fasting C-peptide,FCP)、糖化血红蛋白(hemoglobin A1c,HbA1c)正相关(P<0.05);LFF与空腹胰岛素(fasting plasma insulin,FPI)、FCP正相关,与高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)负相关(P<0.05);KFF与空腹血糖(fasting plasma glucose,FPG)、三酰甘油(triglyceride,TG)正相关,与HDL-C负相关(P<0.05)。脾脏脂肪分数(spleen fat fraction,SFF)与年龄、BMI和各代谢参数间均无相关性。结论衰老影响胰腺脂肪沉积,并可能影响肝脏和肾脏脂肪沉积,对脾脏代谢影响小。Objective To analyze the associations between aging and fat deposition in the pancreas,liver,kidneys,and spleen.Methods A total of 40 subjects were enrolled in the study.Fasting venous blood was collected and abdominal 3T MRI with the six-point Dixon-VIBE subsequence was performed.Fat fraction(FF)was quantified,and biochemical indexes related to glucose metabolism,lipid metabolism and liver and kidney functions were determined.Pearson correlation analysis was used to explore the correlations among variables.Results Pancreatic fat fraction(PFF)had an independent positive correlation with age and a non�independently positive correlation with body mass index(BMI,P<0.05);liver fat fraction(LFF)had an independently positive correlation with BMI and a non-independent association with age(P<0.05);kidney fat fraction(KFF)had a non-independently positive correlations with both age and BMI(P<0.05).There were positive correlations between PFF and LFF or KFF(P<0.05);after adjusted PFF,there was no correlation between LFF and KFF.PFF was positively correlated with fasting C-peptide(FCP)and hemoglobin A1c(HbA1c,P<0.05);LFF was positively correlated with fasting plasma insulin(FPI)and FCP,and was negatively correlated with high-density lipoprotein cholesterol(HDL-C,P<0.05);KFF was positively correlated with fasting plasma glucose(FPG),triglyceride(TG)and was negatively correlated with HDL-C(P<0.05).Spleen fat fraction(SFF)had no correlation with age,BMI and either metabolic parameters.Conclusions Aging significantly affects fat deposition in the pancreas,and may affect fat deposition in the liver and kidneys,with little effect on spleen metabolism.

关 键 词：衰老 异位脂肪沉积 胰腺 肝脏 肾脏 

分 类 号：R589.2[医药卫生—内分泌]