宠物用抗寄生虫药米尔贝肟的研究进展  

Research Progress on Antiparasitic DrugMilbemycin Oxime for Pets

作　　者：段新华 吴寒光 陈雨晴 李颖鑫 刘志昌 柯艳坤 DUAN Xinhua;WU Hanguang;CHEN Yuqing;LI Yingxin;LIU Zhichang;KE Yankun(Shenzhen Animal and Plant Disease Prevention and Control Center,Shenzhen Guangdong 518000;Institute of Animal Science,Guangdong Academy of Agricultral Sciences,Guangzhou Guangdong 510640)

机构地区：[1]深圳市动植物疫病预防控制中心,广东深圳518000 [2]广东省农业科学院动物科学研究所,广东广州510640

出　　处：《广东畜牧兽医科技》2024年第6期57-61,共5页Guangdong Journal of Animal and Veterinary Science

基　　金：广东省重点领域研发计划项目(2023B0202150001);广东省农业科学院协同创新中心项目(XTXM202202)。

摘　　要：米尔贝肟是半合成大环内酯类(Marolides)兽用抗生素,具有广谱、高效、低毒的优点。该药对犬心丝虫表现出特效作用,对犬猫体内外多种寄生虫也具有强烈的驱杀效果。然而,目前对米尔贝肟的研究相对较少,缺乏系统的综述分析。因此,该文对米尔贝肟的理化性质、作用机理、药动学、药效学以及毒性作用等多个方面,旨在为该药在我国宠物临床中的合理应用提供参考。Milbemycin oxime is a semi-synthetic macrolide veterinary antibiotic with the advantages of broad-spectrum,high efficacy,and low toxicity.The drug has a special effect on dog heartworms,and also has a strong repellent effect on a variety of parasites in and out of dogs and cats.However,there are relatively few studies on Milbemycin Oxime at present,and systematic review analysis is lacking.Therefore,this review,covering the physicochemical properties,mechanism of action,pharmacokinetics,pharmacodynamics and toxic effects of Milbemycin Oxime,aiming to provide a reference for the rational application of the drug in pet clinical practice in China.

关 键 词：米尔贝肟 作用机理 药动学 药效学 毒性作用 

分 类 号：S859.795[农业科学—临床兽医学]