基于纳米递送载体的小干扰RNA在肿瘤治疗中的应用  

Application of Small Interfering RNA Based on Nano Delivery Carriers in Tumor Therapy

作　　者：李大伟 杨雪华 毛楷凡 刘正平 薛松 孙利民 LI Da-wei;YANG Xue-hua;MAO Kai-fan;LIU Zheng-ping;XUE Song;SUN Li-min(Shandong Engineering Research Center of New Sustained and Controlled Release Formulations and Drug Targeted Delivery Systems,Shandong Academy of Pharmaceutical Sciences,Jinan 250101,China;NMPA Key Laboratory for Technology Research and Evaluation of Drug Products,Jinan 250101,China;Shandong Provincial Food and Drug Evaluation and Inspection Center,Jinan 250013,China)

机构地区：[1]山东省药学科学院新型缓控释制剂与药物靶向递送系统山东省工程研究中心,山东济南250101 [2]国家药监局药物制剂技术研究与评价重点实验室,山东济南250101 [3]山东省食品药品审评查验中心,山东济南250013

出　　处：《食品与药品》2024年第6期I0050-I0055,共6页Food and Drug

基　　金：山东省重点研发计划-重大科技创新工程项目资助(编号:2021CXGC010515)。

摘　　要：小干扰RNA(siRNA)药物可特异性地调控致病靶基因,疗效好且副作用小。纳米载体系统在siRNA递送方面的主要优点是细胞毒性低,转染效率高,稳定性好,可通过主、被动靶向进行特异性递送,保护核酸分子不被酶降解。本文综述了载siRNA纳米给药系统在肿瘤治疗中的应用进展,以期为肿瘤的治疗提供新的思路。Small interfering RNA(siRNA)drugs can specifically regulate pathogenic target genes,which have good efficacy and minimal side effects.The main advantages of nanocarrier systems in siRNA delivery are low cytotoxicity,high transfection efficiency,good stability,and the ability to perform specific delivery through active and passive targeting and protect nucleic acid molecules from enzymatic degradation.This article reviews the application progress of siRNA loaded nanodelivery systems in tumor therapy,aiming to provide new ideas for tumor treatment.

关 键 词：肿瘤 SIRNA 核酸递送 纳米递送系统 

分 类 号：TQ464.6[化学工程—制药化工]