Krüppel样因子15在代谢调节中的作用  

The Role of KLF15 in Metabolic Regulation

作　　者：衣雪洁[1,3] 李梦焕 杨旸 万根萌 段子强 常波[1] YI Xue-Jie;LI Meng-Huan;YANG Yang;WAN Gen-Meng;DUAN Zi-Qiang;CHANG Bo(School of Sports and Health,Shenyang Sport University,Shenyang 110115,China;School of Sports and Human Sciences,Shanghai Sport University,Shanghai 200438,China;Exercise and Health Research Center/Department of Kinesiology,Shenyang Sport University,Shenyang 110115,China)

机构地区：[1]沈阳体育学院运动健康学院,沈阳110115 [2]上海体育学院运动科学学院,上海200438 [3]沈阳体育学院运动与健康研究中心,沈阳110115

出　　处：《生物化学与生物物理进展》2024年第12期3194-3206,共13页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(12072202)资助项目。

摘　　要：伴随人类生活方式改变,代谢紊乱导致的肥胖、2型糖尿病、非酒精性脂肪性肝病等慢性病已成为严重威胁人类健康的公共卫生问题。Krüppel样因子15 (Krüppel-like factor 15,KLF15)是高度保守的KLF家族成员之一,在多个代谢活跃器官均有表达,具有广泛的调节作用。近年来,大量研究表明,KLF15在脂肪、骨骼肌、肝脏中调节糖、脂、氨基酸代谢,并与营养物质的获取、转运、利用密切相关。本文重点阐述了KLF15对代谢调节中的作用及其机制,期望在更好地理解KLF15的代谢调节作用的基础上,为治疗代谢相关疾病开拓新的视角并推进精准医学。With changes in human lifestyle,chronic diseases caused by metabolic disorders,such as obesity,type 2 diabetes,and non-alcoholic fatty liver disease,have become serious public health issues threatening human health.These diseases not only significantly increase the disease burden on humans but also put immense pressure on global healthcare systems.Therefore,understanding and exploring the molecular mechanisms leading to these diseases,especially the role of metabolic regulators,is crucial for developing effective prevention and treatment strategies.KLF15,one of the highly conserved members of the KLF family,has gained widespread attention due to its expression and regulatory roles in various metabolically active organs.Recent studies have shown that KLF15 regulates glucose,lipid,and amino acid metabolism in adipose tissue,skeletal muscle,and liver,and is closely related to the acquisition,transport,and utilization of nutrients.The role of KLF15 in glucose metabolism is primarily reflected in its regulation of gluconeogenesis and glucose uptake.KLF15 influences blood glucose levels by regulating the expression of key gluconeogenic enzyme phosphoenolpyruvate carboxykinase(PEPCK).Research has shown that KLF15 knockout(KO)mice exhibit severe hypoglycemia and reduced liver glycogen content after 18 h of fasting.Additionally,KLF15 interacts with muscle enhancer factor 2(MEF2A)to activate the GLUT4 promoter,significantly enhancing glucose uptake in skeletal muscle and adipose tissue.In insulinresistant individuals,KLF15 expression is reduced,affecting insulin sensitivity by regulating genes related to lipid metabolism and mitochondrial function.In terms of lipid metabolism,KLF15 expression significantly increases during adipocyte differentiation,regulating the expression of genes such as C/EBPβ,C/EBPδ,and PPARγ.KLF15 KO mice show reduced lipogenesis and increased lipolysis,highlighting its importance in fat storage and energy balance.In brown adipose tissue(BAT),KLF15 regulates genes involved in lipid uptake and ther

关 键 词：Krüppel样因子15 糖代谢 脂代谢 氨基酸代谢 蛋白质代谢 

分 类 号：R723.14[医药卫生—儿科] R587.1[医药卫生—临床医学]