美托洛尔联合盐酸曲美他嗪片对冠心病心力衰竭患者心功能的影响研究  

Study on the Effects of Metoprolol Combined with Trimetazidine Hydrochloride Tablets on Cardiac Function in Emergency Patients with Coronary Heart Disease and Heart Failure

作　　者：邓德明[1] 高璐霞 林美明[1] DENG Deming;GAO Luxia;LIN Meiming(Department of Cardiology,The First Hospital of Sanming City,Fujian Province,Sanming 365000,Fujian)

机构地区：[1]福建三明市第一医院心内科,福建三明365000

出　　处：《中华灾害救援医学》2024年第10期1140-1143,1147,共5页Chinese Journal of Disaster Medicine

摘　　要：目的探讨美托洛尔与盐酸曲美他嗪片联用作为冠心病心力衰竭患者治疗方案的可行性,并进一步分析该方案对患者心功能的影响。方法回顾性选取2022年3月至2024年3月福建三明市第一医院收治的冠心病心力衰竭患者80例,遵循电脑简单化法随机分为对照组38例和观察组42例。对照组采用盐酸曲美他嗪片治疗,观察组采用美托洛尔与盐酸曲美他嗪片联用治疗。将血管内皮功能、氧化应激、心功能、生存质量作为观察指标,比较两组治疗前后的变化。结果两组患者经治疗后,NO较治疗前均升高,内皮素-1(ET-1)较治疗前均降低(P<0.05);经组间比较,观察组治疗后NO水平较对照组升高更显著,ET-1水平较对照组降低更显著(P<0.05)。观察组的丙二醛(MDA)水平在治疗后较治疗前显著降低,对照组的超氧化物歧化酶(SOD)在治疗后较治疗前显著升高(P<0.05),且观察组MDA水平降低更显著(P<0.001),观察组SOD水平升高更显著(P<0.05)。两组患者左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEED)在治疗后均显著降低(P<0.05),且观察组降低更显著(P<0.05)。两组患者左心室射血分数(LVEF)治疗后均较治疗前显著升高(P<0.05),观察组升高更显著(P<0.05)。两组患者C-MLHF各项领域评分组内比较,治疗前较治疗后升高显著(P<0.05);上述各领域治疗后评分观察组较对照组更优(P<0.05)。结论美托洛尔与盐酸曲美他嗪片联用能够从多方面促进急诊冠心病心力衰竭患者心功能的恢复,包括改善血管内皮功能异常状态,减轻氧化应激,提升预后质量等,值得推广。Objective To explore the feasibility of the combination of metoprolol and trimetazidine hydrochloride tablets as a treatment plan for patients with coronary heart disease and heart failure,and further analyze the impact of this plan on patients'cardiac function.Methods A retrospective study was conducted on 80 patients with coronary heart disease and heart failure admitted to the First Hospital of Sanming City,Fujian Province from March 2022 to March 2024.They were randomly divided into a control group of 38 cases and an observation group of 42 cases using a computer simplification method.The control group was treated with trimetazidine hydrochloride tablets,while the observation group was treated with a combination of metoprolol and trimetazidine hydrochloride tablets.Compare the changes in endothelial function,oxidative stress,cardiac function,and quality of life between the two groups before and after treatment.Results After treatment,both groups of patients showed an increase in NO and a decrease in ET-1 compared to before treatment(P<0.05);Through inter group comparison,the observation group showed a more significant increase in NO levels and a more significant decrease in ET-1 levels after treatment compared to the control group(P<0.05).The Malondialdehyde(MDA)level in the observation group decreased significantly after treatment compared to before treatment,while the Superoxide Dismutase(SOD)level in the control group increased significantly after treatment compared to before treatment(P<0.05),and the MDA level in the observation group decreased more significantly(P<0.001),while the SOD level in the observation group increased more significantly(P<0.05).Both groups of patients showed significant reductions in LVESD and LVEED after treatment(P<0.05),with the observation group showing a more significant decrease(P<0.05).Both groups of patients showed a significant increase in LVEF after treatment compared to before treatment(P<0.05),with the observation group showing a more significant increase(P<0.05).The i

关 键 词：美托洛尔 盐酸曲美他嗪片 心力衰竭 

分 类 号：R541.4[医药卫生—心血管疾病]