南征教授应用蛋白1号方加味治疗消渴肾病  

Clinical effect of the modified Protein No.1 prescription in the treatment of diabetic nephropathy by Professor Nan Zheng

作　　者：孟琦 初昀杭 南征[2] 朴春丽 杨明 MENG Qi;CHU Yunhang;NAN Zheng;PIAO Chunli;YANG Ming(Changchun University of Chinese Medicine,Changchun 130117,China;Department of Endocrinology and Metabolism,Affiliated Hospital of Changchun University of Chinese Medicine,Changchun 130021,China;Affiliated Shenzhen Hospital of Guangzhou University of Chinese Medicine,Shenzhen 518000,China)

机构地区：[1]长春中医药大学,长春130117 [2]长春中医药大学附属医院内分泌代谢病科,长春130021 [3]广州中医药大学附属深圳医院<福田>,广州深圳518000

出　　处：《吉林中医药》2024年第12期1440-1442,共3页Jilin Journal of Chinese Medicine

基　　金：吉林省教育厅科学研究项目(JJKH20230965KJ)。

摘　　要：目的观察南征教授蛋白1号方加味治疗消渴肾病的临床效果。方法选取长春中医药大学附属医院就诊的70例消渴肾病患者,随机分为观察组和对照组,各35例。对照组在常规治疗基础上予复方α-酮酸片治疗,观察组在常规治疗基础上给予蛋白1号方加味治疗。比较2组临床疗效、24h尿蛋白定量、空腹血糖(fasting blood glucose,FBG)、餐后2h血糖(postprandial blood glucose,PBG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)及血尿酸(serum uric acid,UA)变化情况。结果观察组总有效率(100%)显著高于对照组48.57%(P<0.05);2组治疗后24 h尿蛋白定量、FBG、PBG、HbA1C、UA均优于治疗前,且观察组优于对照组(P<0.05)。结论蛋白1号方加味可缓解消渴肾病患者临床症状,改善临床指标,提高患者生存质量,为中医药治疗消渴肾病提供新的思路。Objective To explore the clinical effect of the modified Protein No.1 prescription created by Professor Nan Zheng in the treatment of diabetic nephropathy.Methods A total of 70 patients with diabetic nephropathy who visited the Affiliated Hospital of Changchun University of Chinese Medicine were randomly divided into an observation group and a control group,with 35 patients in each group.The control group was treated with compoundα-keto acid tablets on the basis of a routine treatment,while the observation group was treated with the modified Protein No.1 prescription on the basis of a routine treatment.The clinical efficacy,the levels of 24-hour urinary protein quantification,fasting blood glucose(FBG),2-hour postprandial blood glucose(PBG),glycosylated hemoglobin(HbA1c)and serum uric acid(UA)were observed in the two groups.Results The total effective rate of the observation group was 100%,significantly higher than that of the control group(48.57%,P<0.05).After treatment,the levels of 24-hour urinary protein,FBG,PBG,HbA1C,and UA were better in both groups than before treatment,and the observation group was better than the control group(P<0.05).Conclusion The Protein No.1 prescription is effective in the treatment of diabetic nephropathy,which can alleviate clinical symptoms,improve clinical indicators,and enhance the quality of life of patients,providing a new idea for the treatment of diabetic nephropathy with traditional Chinese medicine.

关 键 词：消渴肾病 毒损肾络学说 蛋白1号方 南征 

分 类 号：R255.4[医药卫生—中医内科学]